Tuberculosis and Malaria are two major infectious diseases caused by species belonging to Mycobacterium and Plasmodium, respectively, and they are a significant cause of morbidity and mortality worldwide. Despite widespread awareness and knowledge, the eradication of these diseases remains a distant goal. One of the primary challenges in controlling these diseases is the ability of the infectious microbes to develop resistance against all available drugs and antibiotics. The development of resistance is a complex process driven by environmental, genetic, and evolutionary factors. Recent studies have highlighted the multifaceted nature of resistance mechanisms, yet there remain significant gaps in our understanding. Addressing these gaps is crucial for formulating effective strategies to combat resistance and preserve the efficacy of antimicrobial therapies.

This research topic aims to assemble a collection of state-of-the-art research articles that bring novel insights into the mechanisms contributing to the development of drug resistance. Specifically, we seek to understand the genetic, environmental, and evolutionary factors that drive resistance in infectious microbes. By identifying new drugs and drug targets, we hope to develop strategies that can effectively combat resistance and improve the efficacy of current treatments. The primary objective is to answer key questions about the mechanisms of resistance and to test hypotheses related to the development and spread of drug-resistant strains.

To gather further insights into the upsurge of resistance in infectious microbes, we welcome articles addressing, but not limited to, the following themes:
- Exploring the role of genes and their mutations in the development of resistance.
- Insight into the role of biofilm formation in the development of resistance.
- Novel insights into the role of immune evasion in the development of resistance.
- Identification of novel druggable targets and drug molecules.
- Role of membrane proteins or transporters in drug resistance.
- Impact of drug resistance on host-pathogen interactions.
- Updates on the mechanisms of antibiotic action and resistance.
- Effect of environment and nutrients on the emergence of drug resistance.
- Epidemiological studies addressing concerns over increased drug resistance.

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Frontiers in Cellular and Infection Microbiology

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