About this Research Topic
Dysfunction of the blood brain barrier (BBB) plays an important role in the initiation as well as progression of neurodegenerative processes. We are now beginning to understand the complex, yet specific roles of individual cellular components within the BBB at the molecular level in triggering, mediating, and even sustaining neurodegeneration. Given the exciting and emerging research in this area, we invite articles that include, but are not limited to: (i) The molecular mechanisms played by specific cells of the BBB in causing dysfunction and death of neurons, glia and other cell types within the CNS. (ii) New approaches and techniques for studying BBB function and dysfunction, structure and its relationship to neurodegenerative diseases. (iii) Therapeutic approaches for manipulating BBB function in the context of neurodegenerative diseases. (iv) Novel biomarkers to detect BBB dysfunction. (v) Interactions between the BBB and other systems, such as the gastrointestinal tract, immune, cardiovascular and endocrine systems.
A major gap in the area of BBB biology is that we do not fully understand how the BBB, and more specifically different cell types within the BBB, interact at a molecular and / or systems level prior to and during neurodegenerative processes. This Research Topic aims to fill some of the major knowledge gaps in this area with a special focus on the interaction of specific cell types in the BBB with different types of neurodegenerative diseases.
This research topic is broad in its scope. It encompasses the relationship between BBB components and origin of different types of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, stroke, traumatic brain injury. We invite the following types of articles for submission to this special issue: (i) Primary research articles and short communications (mechanistic, preclinical and clinical studies) (ii) Reviews (iii) Mini-reviews (iv) Perspective articles.
A major gap in the area of BBB biology is that we do not fully understand how the BBB, and more specifically different cell types within the BBB, interact at a molecular and / or systems level prior to and during neurodegenerative processes. This Research Topic aims to fill some of the major knowledge gaps in this area with a special focus on the interaction of specific cell types in the BBB with different types of neurodegenerative diseases.
This research topic is broad in its scope. It encompasses the relationship between BBB components and origin of different types of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, stroke, traumatic brain injury. We invite the following types of articles for submission to this special issue: (i) Primary research articles and short communications (mechanistic, preclinical and clinical studies) (ii) Reviews (iii) Mini-reviews (iv) Perspective articles.
Keywords: smooth muscle cells, astrocytes, pericytes, vasculature associated microglia, endothelial cells, perivascular fibroblasts, iPSCs, Alzheimer's disease, Parkinson's disease, Huntington's diease, Amyotrophic lateral sclerosis, stroke, traumatic brain injury
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