Over the last decade, the field of neurodegenerative disease treatment has experienced significant transformation due to the emergence of innovative therapeutic options. Previously unexplored treatment modalities, particularly monoclonal antibodies, have shown potential as disease-modifying agents in conditions like Alzheimer’s disease, signaling a paradigm shift in their management. Despite these advances, the complete impact of these novel therapeutics on the spectrum of neurological disorders remains to be fully assessed. The ongoing development of these therapies highlights a clear need for an integrated approach, incorporating new chemical entities, advanced delivery mechanisms, and the identification of unique molecular targets.

This Research Topic aims to highlight both the foundational and clinical research that serves as the backbone for emerging therapies in neurodegenerative diseases. By focusing on the latest developments spanning biology, chemistry, and clinical studies, this collection intends to create a comprehensive understanding that bridges gaps between basic science and clinical applications. The goal is to flesh out the current research landscape, detail barriers to current treatment modalities, pioneer innovative therapeutic methods, and provide a forward-looking perspective on the treatment of neurodegenerative conditions.

To thoroughly explore this rapidly evolving field, contributions to this topic should be well-defined yet broad in outreach, covering several crucial areas:

Molecular Mechanisms: Understanding the biological underpinnings that lead to neurodegeneration.

Therapeutic Agents: Development and optimization of new pharmacological interventions, such as monoclonal antibodies.

Drug Delivery Systems: Innovations in the methods used to administer these new treatments effectively across the blood-brain barrier.

Clinical Trials and Studies: Insights from recent clinical trials, including patient outcomes and methodological approaches.

Transdisciplinary Methods: Integration of diverse scientific disciplines to forge new paths in treatment development.

Policy and Ethical Considerations: Addressing the implications of new therapies on healthcare policies and ethical debates.

This approach will not only expand the current state of knowledge but will also foster the development of strategic frameworks necessary for the successful integration of new treatments into standard care practices for neurodegenerative diseases. By inviting research from various specialties, we aim to foster a holistic view that will pave the way for effective and groundbreaking therapies in the field.

To achieve a comprehensive overview of current research, this collection will prioritize Original Research articles, including those that describe new Methods, Case Reports, or Clinical Trials, comprising 50% of the accepted submissions. Additionally, we welcome submissions of various article types such as General Commentaries, Mini Reviews, Opinions, Perspectives, and Reviews. This diverse array of contributions will ensure a rich and holistic exploration of the advances and future directions in the treatment of neurodegenerative diseases.

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Frontiers in Drug Discovery

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