Microorganisms have the ability to interact with larger organisms in various ways, ranging from beneficial symbiosis to neutral commensalism, and even to harmful pathogenicity. The intricate network of internal connections within a host determines the progression of a disease. Therefore, comprehending these host-pathogen interactions from a one health perspective is crucial in the development of treatments and preventive measures against infectious diseases.

The One Health approach recognizes that the health of humans is closely connected to the health of animals and our shared environment. By integrating data and methods from these interconnected areas, we can develop more effective strategies for preventing and controlling infectious diseases at a global level.

Extensive research on the interactions between pathogens and hosts has identified the most significant factors influencing the course of infections. From the perspective of the pathogen, these studies aid in the identification of virulence factors that can be targeted by anti-virulence strategies, which are less likely to develop resistance compared to anti-viability agents. Furthermore, these studies shed light on the metabolic and homeostatic components of the host that have the greatest impact on disease resistance or susceptibility.

This Research Topic aims to encompass all aspects of pathogenic microorganisms, including bacteria, yeasts, protozoa, and parasites, and their interactions with host organisms from a one health perspective. Focusing on the One Health aspect, this Research Topic will highlight studies that provide insights into how changes in the environment, animal health, and human activities influence disease dynamics. Research addressing the intertwined nature of these sectors will enable the identification of shared risk factors and promote holistic interventions that benefit all components of the One Health triad.

This Research Topic seeks to compile research on diseases that analyze the interdependence and interconnectedness of the environmental, animal, and human sectors from a one-health standpoint. The application of the One Health approach can facilitate early detection and response to outbreaks, improve our understanding of disease dynamics, and foster collaborative efforts across disciplines to ensure comprehensive health outcomes.

Original research and review articles focusing on (but not limited to) the following sub-themes are welcome.
• Advanced diagnostic and detection tools for early and rapid identification of zoonotic and emerging infectious diseases to enhance outbreak control and management
• The influence of environmental changes in the interactions between hosts and pathogens (for example, pathogen transmission and persistence) and subsequent disease dynamics
• Disease mechanisms, cross-species transmission between humans and animals, including zoonotic diseases, and integrated health management practices to enhance overall health of humans and animals
• Interdisciplinary strategies showcasing the benefits of collaborative research and practical applications that bridge human, animal, and environmental health
• Surveillance systems that monitor disease trends across human, animal, and environment for outbreak preparedness, early detection and coordinated response

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Frontiers in Cellular and Infection Microbiology

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