About this Research Topic
Cell division control is an integral mechanism crucial for growth, tissue repair, and proper development.
When the cell cycle control is broken, it can lead to uncontrolled cell proliferation and the formation of tumors. To prevent errors in the cell division process, cell cycle operates under tight regulation, employing different checkpoints that ensure accurate DNA replication and cell division. Dysregulation in checkpoint
controls, replication errors, or defects in DNA repair mechanisms can induce genomic instability that is a hallmark of many cancers and contributes to the heterogeneity observed within tumors. Furthermore, cancer cells often develop the capability to persist in erroneous cell division cycles, even when confronted with systemic therapies. Thus, understanding the intricate molecular mechanisms governing cell cycle regulation and checkpoint controls is essential for developing targeted therapies.
This Research Topic will center on exploring the intricate molecular pathways and networks that control cell cycle regulation and checkpoints. The topic aims to delve into experimental and computational studies that reveal and explain molecular mechanisms governing cell division specifically in the context of cancer. We welcome investigators to contribute their latest original research articles as well as review articles and perspectives on the characterization of the cell division regulation.
This Research Topic is open, but not limited to, research relating to the following themes:
• Cell cycle regulation in cancer cells.
• Molecular circuits controlling checkpoints.
• Mechanisms that regulate the size and proliferation of cells within an organism.
• Crosstalk between cell cycle regulation and other relevant molecular pathways.
• Molecular mechanisms that contribute to acquired drug resistance in cancer.
When the cell cycle control is broken, it can lead to uncontrolled cell proliferation and the formation of tumors. To prevent errors in the cell division process, cell cycle operates under tight regulation, employing different checkpoints that ensure accurate DNA replication and cell division. Dysregulation in checkpoint
controls, replication errors, or defects in DNA repair mechanisms can induce genomic instability that is a hallmark of many cancers and contributes to the heterogeneity observed within tumors. Furthermore, cancer cells often develop the capability to persist in erroneous cell division cycles, even when confronted with systemic therapies. Thus, understanding the intricate molecular mechanisms governing cell cycle regulation and checkpoint controls is essential for developing targeted therapies.
This Research Topic will center on exploring the intricate molecular pathways and networks that control cell cycle regulation and checkpoints. The topic aims to delve into experimental and computational studies that reveal and explain molecular mechanisms governing cell division specifically in the context of cancer. We welcome investigators to contribute their latest original research articles as well as review articles and perspectives on the characterization of the cell division regulation.
This Research Topic is open, but not limited to, research relating to the following themes:
• Cell cycle regulation in cancer cells.
• Molecular circuits controlling checkpoints.
• Mechanisms that regulate the size and proliferation of cells within an organism.
• Crosstalk between cell cycle regulation and other relevant molecular pathways.
• Molecular mechanisms that contribute to acquired drug resistance in cancer.
Keywords: Cell division, cell cycle, checkpoints, molecular circuits, molecular networks, pathways
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
