Autophagy is a vital cellular process that maintains homeostasis by degrading intracellular components, such as damaged organelles and proteins. It plays a crucial role in the host immune response to infections by eliminating intracellular pathogens and limiting their replication. Additionally, autophagy can induce cell death, preventing the spread of infection to neighboring cells. Recent studies have highlighted the complexity and dynamism of the interplay between autophagy and cell death, particularly in the context of host responses to infections. Aquatic animals, constantly exposed to various pathogens and environmental stressors, rely on a sophisticated immune system comprising both innate and adaptive responses. Despite some research into the induction of autophagy and cell death during pathogen infections in aquatic animals, our understanding remains limited. Notably, recent findings suggest that autophagy alleviates ER stress to facilitate proper mucus secretion, a critical defense mechanism in aquatic animals. However, further exploration is needed to fully elucidate the pathways of autophagy and cell death in these organisms and their roles in immune responses.

This research topic aims to deepen our understanding of the interaction between host autophagy, cell death, and immune responses against pathogen invasion in aquatic animals. It seeks to provide insights into the evolutionary similarities and differences in autophagy and cell death mechanisms between aquatic animals and primates. By exploring these interactions, the research aims to uncover ancient defense mechanisms, understand the development of autophagy and cell death, and potentially develop new therapeutic strategies to enhance the health of economically significant aquatic species.

To gather further insights into the molecular and cellular aspects of autophagy and cell death in aquatic animals, we welcome articles addressing, but not limited to, the following themes:
- Molecular mechanisms involved in the crosstalk between autophagy, cell death, immune response, and cellular communication.
- Roles of autophagy and cell death in the mucosal defense system and the development of immune cells in aquatic animals.
- Evolutionary or comparative analysis of autophagy and cell death pathways in aquatic animals.
- Impact of feed additives, drugs, pollutants, and the water environment on autophagy and cell death responses affecting aquatic animal health.
- Influence of gut microbiota and metabolites on host autophagy, cell death, and immune response in aquatic animals.

We encourage the submission of Original Research article and Review articles will also be considered.

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Frontiers in Immunology

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