The field of dermatology has witnessed remarkable progress in the prevention and treatment of skin diseases over the past decade. This progress is largely attributed to a deeper understanding of the pathophysiology of these conditions, which has paved the way for the development of innovative drugs and medical devices. Chronic inflammatory disorders such as atopic dermatitis and psoriasis, as well as rare inherited skin diseases like Xeroderma pigmentosum, have seen significant advancements in treatment options. Biologics, small molecule inhibitors, and enzyme therapies have emerged as pivotal tools in this regard. Biologics, such as Dupilumab and Secukinumab, target specific cytokines and receptors, while small molecule inhibitors like Phosphodiesterase 4 (PDE) Inhibitor and Deucravacitinib interact with intracellular signaling molecules. Enzyme therapies, including photolyase and T4 endonuclease V, aim to replace deficient or absent enzymes in the body. Despite these advancements, there remains a need to continually evaluate the efficacy and side effects of these therapeutics, as numerous options are still under investigation.

This research topic aims to consolidate the latest findings in skin precision medicine, focusing on the prevention and treatment of skin diseases. The primary objective is to gather original research articles and comprehensive reviews that explore recent advancements in this field. Key questions include the effectiveness of novel immunotherapeutic approaches, the potential of gene editing technologies in correcting genetic mutations, and the role of DNA repair mechanisms in maintaining skin health. Additionally, the research will investigate innovative drug delivery systems and the impact of enzyme replacement therapies on rare inherited skin disorders.

To gather further insights in the prevention and treatment of skin diseases, we welcome articles addressing, but not limited to, the following themes:

• Immunotherapy: the latest developments in immunotherapeutic approaches for treating skin diseases, including novel biologics targeting immune cells or cytokines involved in inflammatory pathways.
• Gene Editing Techniques: the application of CRISPR/Cas9 and other gene editing technologies in correcting genetic mutations underlying inherited skin disorders.
• DNA Repair Mechanisms: the role of DNA repair pathways in maintaining skin homeostasis and their dysregulation in diseases like skin cancer.
• Innovative Drug Delivery Systems: the use of drug delivery systems such as nanoparticles, microneedles, or liposomal formulations, designed to improve the localized delivery and efficacy of dermatological therapeutics while minimizing systemic toxicity and side effects.
• Enzyme Replacement Therapies: the role and effectiveness of enzyme therapies in addressing deficiencies associated with rare inherited skin disorders.

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Frontiers in Pharmacology

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