We are now in the third decade of the 21st Century, and especially in recent years, scientists have made exceptional achievements, leading to major advancements in the fast-growing field of Vascular Physiology. This Frontiers Research Topic aims to highlight the latest advancements in vascular physiology and pathophysiology, including novel developments, current challenges, latest discoveries, recent advances, and future perspectives. It is edited by Topic Editors Prof. Irena Levitan (University of Illinois Chicago, USA), Prof. Christopher Garland (University of Oxford, UK) and Prof. Luis A. Martinez-Lemus (University of Missouri, USA).

The Research Topic solicits forward-looking contributions from the editorial board members that describe the state of the art, outlining, recent developments and major accomplishments that have been achieved and that need to occur to move the field forward. Authors are encouraged to identify the greatest challenges in the sub-disciplines, and how to address those challenges. This article collection will inspire, inform and provide direction and guidance to researchers in the field.

We welcome submissions related to, but not limited to, the following topics:

• Mechanisms of Abdominal Aortic Aneurysm (AAA) progression to rupture to identify targets for its therapeutic amelioration;
• Integration of shear stress mechanotransduction in endothelial cells;
• Mechanisms of endothelial to smooth muscle cell communication across vascular beds;
• Mechanisms of cerebral capillary perfusion in health and disease;
• Endothelial contributions to metabolic dysfunction;
• Vascular effects of the new anti-obesity drugs;
• Lipid-proteins interactions and lipidomics in vascular dysfunction;
• Impact of microbiome on vascular physiology and health and disease;
• Vascular aging;
• Regulation of the cerebral microcirculation;
• Regulation of the coronary microcirculation - with special interest in dysfunction particularly in angina or ischemia with no obstructive coronary disease (ANOCA/INOCA);
• Ion channels in vascular and endothelial function.

Topic Editor Prof. Luis A. Martinez-Lemus holds a patent entitled "Neuraminidase inhibition to improve glycocalyx volume and function to ameliorate cardiovascular diseases in pathologies associated with glycocalyx damage". All other Topic Editors declare no conflicts of interest.

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Frontiers in Physiology

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