Post-Translational Modifications (PMTs) are necessary for proteins to respond to intrinsic and extracellular environmental signals. PTMs comprise a variety of derivatizations like methylation, glycosylation, ubiquitylation, palmitoylation, myristoylation, prenylation, acetylation, phosphorylation, hypusination and epigenetic PMTs. Their functions have been investigated only in a few parasites and are attributed to cell growth, stress response, stage specific transition, gametogenesis and elongation of translation. However, information on their role in pathogenesis and infection is scarce. In this context, with respect to One Health, delineation of PMT function in infection would tremendously improve the treatment of parasitic diseases with novel drug entities, immunotherapies and Advanced Medicinal Therapies.
Keywords:
PTMs, Epigenetic PTMs, Parasitic infection, Novel Therapies, Advanced Medicinal Therapies
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Post-Translational Modifications (PMTs) are necessary for proteins to respond to intrinsic and extracellular environmental signals. PTMs comprise a variety of derivatizations like methylation, glycosylation, ubiquitylation, palmitoylation, myristoylation, prenylation, acetylation, phosphorylation, hypusination and epigenetic PMTs. Their functions have been investigated only in a few parasites and are attributed to cell growth, stress response, stage specific transition, gametogenesis and elongation of translation. However, information on their role in pathogenesis and infection is scarce. In this context, with respect to One Health, delineation of PMT function in infection would tremendously improve the treatment of parasitic diseases with novel drug entities, immunotherapies and Advanced Medicinal Therapies.
Keywords:
PTMs, Epigenetic PTMs, Parasitic infection, Novel Therapies, Advanced Medicinal Therapies
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.