Small molecule probes are chemical compounds designed to interact selectively with specific biological targets, such as proteins or nucleic acids, providing researchers with a powerful tool to study and manipulate biological processes. These probes are invaluable in pharmacological research as they enable the elucidation of complex cellular pathways, the identification of drug targets, and the evaluation of drug efficacy and safety. By precisely modulating target activity, small molecule probes offer insights into disease mechanisms and potential therapeutic interventions. This Research Topic aims to explore the advancements and applications of small molecule probes in pharmacological research. From novel probe design strategies to innovative screening methodologies, we seek to showcase the diverse roles and impact of small molecule probes in drug discovery, target validation, and personalized medicine. Through a comprehensive examination of current research trends and emerging technologies, we aim to provide researchers with valuable insights and inspire further advancements in the field of pharmacology.

In this Research Topic, we welcome articles focusing on:

Novel design strategies for small molecule probes targeting specific biological pathways or molecular targets.

Innovative screening methodologies for identifying and characterizing small molecule probes with desired pharmacological properties.

Case studies highlighting the use of small molecule probes in elucidating disease mechanisms and identifying potential therapeutic interventions.

Applications of small molecule probes in drug discovery, target validation, and personalized medicine.

Reviews or perspectives discussing current research trends, challenges, and future directions in the field of small molecule probe development and application in pharmacology.

These articles will contribute to advancing our understanding of small molecule probe pharmacology and its implications for therapeutic development and personalized medicine.

We welcome a variety of article types, including under the following categories: Original Research, Review, Mini Review, Brief Research Report, and Perspective.

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Frontiers in Pharmacology

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