Immune Cells in Nerve Regeneration: Mechanisms and Therapeutic Implications

Immune cells, including macrophages, T cells, and microglia, have emerged as key players in the process of nerve regeneration and repair. This Research Topic aims to unravel the multifaceted roles of immune cells in modulating the microenvironment following nerve injury, including their effects on inflammation resolution, tissue remodeling, and axonal regeneration. Nerve regeneration is crucial for functional recovery post-injury or disease. However, this process faces obstacles such as inflammation and immune responses at injury sites. Understanding the complex interactions between immune cells and nerve regeneration is pivotal for developing effective therapeutic interventions.



This research topic aims to elucidate the multifaceted roles of immune cells, including macrophages, T cells, and microglia, in regulating the microenvironment surrounding injured nerves. We seek to explore the molecular mechanisms underlying immune cell involvement in nerve regeneration and discuss the potential therapeutic interventions targeting immune cells for enhancing nerve recovery for various neurological disorders. We invite contributions to discuss Through this Research Topic, we aim to advance our understanding of immune-neural interactions and pave the way for innovative approaches in nerve injury treatment.



We welcome original research articles, reviews, and perspectives that delve into immune cell-mediated nerve regeneration. Topics of interest include the roles of immune cells in tissue clearance, debris removal, growth factor secretion, and modulation of inflammation. Authors are encouraged to discuss potential therapeutic targets and strategies for enhancing nerve repair and functional recovery. Manuscripts should adhere to Frontiers' guidelines and provide insights into the mechanisms driving immune cell involvement in nerve regeneration. Join us in advancing our understanding of immune cells' contributions to nerve regeneration and their therapeutic potential in neurological disorders.

Keywords: Nerve regeneration, Immune Cells, Inflammation, Molecular Mechanisms, Neurotherapeutics

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.