Platelet aggregation is a critical multistep process pivotal in both hemostasis and thrombosis. This complex sequence begins with platelet adhesion to damaged vessel walls, followed by activation and release of signaling molecules that recruit more platelets. This cascade leads to the formation of a platelet plug. Concurrently, thrombin converts fibrinogen to fibrin, creating a mesh that strengthens the clot. Dysregulation in this process not only causes thrombotic disorders such as deep vein thrombosis and arterial clots but also contributes to other platelet-related conditions. Platelet-activating factor (PAF) plays a significant role in these mechanisms through its involvement in inflammation and thrombosis.

Blockage of blood vessels due to thrombus can severely impede blood flow, causing a spectrum of health complications. Venous thrombi are often linked with localized swelling and pain, while detached thrombi can lead to pulmonary embolism. Arterial thrombi, on the other hand, are closely associated with cardiovascular diseases, including myocardial infarction and ischemic stroke. This research aims to explore both the fundamental mechanisms of platelet aggregation and its disorders, and innovative prevention and treatment strategies. Special attention is given to the potential of herbal medicines, which have shown promising efficacy in moderating platelet activity and treating thrombotic diseases.

The research topic seeks contributions that extend beyond thrombosis to encompass a broader range of platelet-related disorders and PAF modulation. We welcome studies focused on the biological and molecular underpinnings of platelet aggregation, innovative therapeutic strategies, and the role of herbal medicines in these contexts. Studies should focus on:

• Mechanisms underlying platelet aggregation and related disorders
• Innovative prevention and treatment strategies for platelet aggregation-related diseases
• The role of herbal medicines in preventing and treating platelet aggregation
• Molecular mechanisms of antithrombotic and anti-platelet herbal medicines
• Screening and evaluation of anti-platelet herbal compounds

This inclusive approach aims to gather comprehensive insights into platelet function and modulation, facilitating advancements in both conventional and alternative therapies for platelet-related health issues.

Please self-assess your MS using the ConPhyMP tool (https://ga-online.org/best-practice/), and follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205. All the manuscripts need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here). Importantly, please ascertain that the ethnopharmacological context is clearly described (pillar 3d) and that the material investigated is characterized in detail (pillars 2 a and b).

Submit your idea

Impact

Frontiers in Pharmacology

Submit your idea

Impact