The field of endothelial injury syndromes has undergone a significant transformation in recent decades. Initially perceived as a simple anatomical structure, the endothelium is now recognized as a dynamic organ with multifaceted roles in maintaining physiological homeostasis. It is actively involved in regulating coagulation, vascular tone, permeability, and inflammatory responses. When the endothelium is activated, it can lose its integrity, leading to phenotypic changes that trigger procoagulant, pro-inflammatory, and pro-apoptotic mediators. This dysfunction is central to a range of hematological conditions and other diseases, including cardiovascular, pulmonary, inflammatory, and tumoral disorders characterized by vascular injury. Despite the growing attention to endothelial injury syndromes, many questions remain unanswered. There is a need for further research to understand the mechanisms by which endothelial injury contributes to these disorders, develop robust markers for assessing the severity and progression of these syndromes, and explore the endothelium as a potential therapeutic target.

This research topic aims to explore the multifaceted roles of endothelial injury syndromes in hematology and beyond. The primary objectives include elucidating the mechanisms underlying endothelial injury in various vascular-related disorders, identifying and developing markers for assessing the severity and progression of these syndromes, and investigating the potential of the endothelium as a therapeutic target. By addressing these objectives, the research seeks to advance our understanding of endothelial dysfunction and its implications across different medical specialties.

To gather further insights into the complex landscape of endothelial injury syndromes, we welcome articles addressing, but not limited to, the following themes:

- Hematological disorders
- Cardiovascular diseases
- Chronic inflammatory disorders
- Oncology
- Transplantation

This interdisciplinary approach encourages collaboration among basic, translational, and clinical researchers from various specialties, including hematology, cardiology, inflammatory and infectious diseases, nephrology, oncology, and transplantation, to facilitate the exchange of new concepts and update state-of-the-art knowledge.

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Frontiers in Medicine

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