Endothelial Injury Syndromes in Hematology and Beyond

The initial ''anatomical'' perception of endothelium as a mere single-cell layer lining the inner wall of blood and lymph vasculature has dramatically evolved over the past decades. The endothelium is now recognized as a dynamic organ with diverse functional capabilities and a crucial role in maintaining homeostasis. It actively modulates a variety of processes, including the regulation of coagulation, vascular tone, permeability, and inflammatory processes. When activated, the endothelium loses its integrity, and its phenotypic changes can trigger procoagulant, pro-inflammatory, and pro-apoptotic mediators, often resulting in endothelial dysfunction and injury. Significantly, endothelial dysfunction lies at the heart of several hematological conditions and numerous cardiovascular, pulmonary, inflammatory, and tumoral diseases characterized by vascular injury.

Although endothelial injury syndromes have garnered increasing attention over the past few years, numerous questions remain unanswered in this complex field. Further studies are needed to elucidate the mechanisms by which endothelial injury contributes to various vascular-related disorders. Moreover, the development of robust markers for assessing the severity and progression of endothelial injury syndromes is a pressing need. The role of the endothelium as a potential therapeutic target in hematology and beyond also commands further investigation. This interdisciplinary approach, which brings together basic, translational, and clinical researchers across different specialties (hematology, cardiology, inflammatory and infectious diseases, nephrology, oncology, transplantation), aims to facilitate the exchange of new concepts and update state-of-the-art knowledge.

This Research Topic is interested in publishing Original Research, Systematic Review, Methods, Review, Mini Review, Policy and Practice Reviews, Hypothesis and Theory, Perspective, Clinical Trial, Case Report, General Commentary, and Opinion articles. Topics may include (but are not limited to) studies in endothelial dysfunction or endothelial injury in the following areas:

• Hematological disorders

• Cardiovascular diseases

• Chronic inflammatory disorders

• Oncology

• Transplantation

Keywords: Endotheliopathies, Endothelial Dysfunction, Endothelial Injury Syndromes, Microcirculation, Hematology, Cardiovascular Disease, Vascular Inflammation

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