Cancer represents the second major cause of death worldwide. Since the FDA approved cisplatin as a chemotherapy drug for cancer treatment in 1978, several generations of platinum-based derivatives have been developed. However, none of them have been entirely successful in treating this fatal disease. The shortcomings of these drugs, especially cisplatin, include significant side effects such as neurotoxicity, nephrotoxicity, ototoxicity, reduced immunity, gastrointestinal disorders, kidney and liver failure, and tumor resistance to cisplatin. These findings fueled extensive research and design of alternative new and more effective metal-based anticancer agents with better pharmacological profiles. During the last 40 years, numerous complexes involving various metals, containing a combination of various inorganic anions and/or organic molecules as ligands, have been researched, and new mechanisms of action have been discovered and thoroughly studied at suitable in vitro and in vivo models, however, only few metal complexes entered clinical trials successfully.
Original research works contributing to the knowledge in this Research topic, mainly oriented on the preparation, thorough characterization, and biological testing of the anticancer activities of the metal complexes are invited. Original research works bringing deeper insights into the mechanism of action of metal complexes (including proteomic, pharmacogenomic and ADME-TOX studies) and original contributions involving the structure-activity relationship (SAR) studies in suitably designed groups of metal complexes are also sought.
This Special Issue, "Metal Complexes as Prospective Antiproliferative Agents for Cancer Therapy " of the Frontiers in Chemistry journal, in the Inorganic Chemistry section or which one to choose? will comprise a selection of regular research papers, short communications or reviews covering various aspects of a multidisciplinary field related to metal complexes with considerable antiproliferative activity. We warmly invite authors to submit contributions dedicated to any of the issues of this research area.
Manuscripts can be submitted online at https://www.frontiersin.org/journals/chemistry or directly via Inorganic Chemistry section at https://www.frontiersin.org/journals/chemistry/sections/inorganic-chemistry, and until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited.
Keywords:
metal complexes as anticancer; antiproliferative; biological testing in vitro and in vivo; cellular effects
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Cancer represents the second major cause of death worldwide. Since the FDA approved cisplatin as a chemotherapy drug for cancer treatment in 1978, several generations of platinum-based derivatives have been developed. However, none of them have been entirely successful in treating this fatal disease. The shortcomings of these drugs, especially cisplatin, include significant side effects such as neurotoxicity, nephrotoxicity, ototoxicity, reduced immunity, gastrointestinal disorders, kidney and liver failure, and tumor resistance to cisplatin. These findings fueled extensive research and design of alternative new and more effective metal-based anticancer agents with better pharmacological profiles. During the last 40 years, numerous complexes involving various metals, containing a combination of various inorganic anions and/or organic molecules as ligands, have been researched, and new mechanisms of action have been discovered and thoroughly studied at suitable in vitro and in vivo models, however, only few metal complexes entered clinical trials successfully.
Original research works contributing to the knowledge in this Research topic, mainly oriented on the preparation, thorough characterization, and biological testing of the anticancer activities of the metal complexes are invited. Original research works bringing deeper insights into the mechanism of action of metal complexes (including proteomic, pharmacogenomic and ADME-TOX studies) and original contributions involving the structure-activity relationship (SAR) studies in suitably designed groups of metal complexes are also sought.
This Special Issue, "Metal Complexes as Prospective Antiproliferative Agents for Cancer Therapy " of the Frontiers in Chemistry journal, in the Inorganic Chemistry section or which one to choose? will comprise a selection of regular research papers, short communications or reviews covering various aspects of a multidisciplinary field related to metal complexes with considerable antiproliferative activity. We warmly invite authors to submit contributions dedicated to any of the issues of this research area.
Manuscripts can be submitted online at https://www.frontiersin.org/journals/chemistry or directly via Inorganic Chemistry section at https://www.frontiersin.org/journals/chemistry/sections/inorganic-chemistry, and until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited.
Keywords:
metal complexes as anticancer; antiproliferative; biological testing in vitro and in vivo; cellular effects
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.