C-reactive protein (CRP) serves as a critical biomarker in inflammatory conditions, synthesized predominantly by the liver in response to inflammatory cytokines. Despite its pivotal role in the innate immune system and being a subject of study for nearly a century, definitive functions of CRP in inflammation remain elusive. Further complexity is introduced as CRP exhibits versatility in binding to phosphocholine and activating the complement system, suggesting variant forms with potentially distinct biological activities. Recent inquiries into structure-function relationships and comparative studies across species underline the necessity for deeper examination into CRP's roles across various physiological and pathological contexts.

This Research Topic aims to comprehensively explore CRP gene expression mechanisms, the structural and functional dynamics of CRP across the animal kingdom, and its applications in understanding and managing infectious and non-infectious diseases and inflammation. A thorough grasp of CRP biology is crucial for the development of innovative therapeutic strategies targeting this protein to treat various inflammatory disorders effectively.

To elucidate the broad implications of CRP in health and disease, we invite contributions that encompass a range of studies focused on:

- Functions of CRP in diverse inflammatory conditions including autoimmune, infectious, cardiovascular, and neurodegenerative diseases
- Detailed analysis of CRP's structure-function relationships
- Complement activation by CRP and its complexes
- Potential of CRP as a therapeutic agent or a target for new treatments
- Diagnostic and therapeutic roles of serum CRP levels in inflammatory diseases
- CRP's involvement in COVID-19
- Regulatory mechanisms of CRP gene expression in varied states
- Evolutionary aspects of CRP and its role in the primitive immune system
- Comparative studies on CRP homologs including SAP and PTX3

We welcome a variety of article formats, including Original Research, Review, and more, aiming to fuse molecular biology with clinical insights to shape future research and treatment paradigms.

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Frontiers in Immunology

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