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The Pharmacological Effects and Mechanisms of Drugs Against Human Diseases by Modulating Redox Homeostasis

Redox homeostasis is a dynamic cellular steady state which maintains a balance between oxidants and reductants. Both oxidant and antioxidant signals are key features of redox homeostasis. Moreover, reactive oxygen species (ROS) are highly reactive oxidants when undergoing cellular oxidative stress that plays significant roles in cell signaling, metabolism, survival, development, and death. Dysregulation of redox homeostasis is involved in various human diseases. In fact, abnormally elevated ROS levels are found in diverse diseases such as infections, ischemic traumas, chronic inflammatory diseases, and neurodegenerative diseases. In these cases, scavenging excessive free radicals using antioxidative molecules may prove beneficial for these diseases. In other cases, such as cancer chemotherapy, drugs enhance the ROS signal of cancer cells to promote cell death and act synergistically with chemotherapeutic agents. Overall, the balancing of redox in cells may provide beneficial effects for human health.

Since redox homeostasis has broad effects on human health and diseases, the limited effect of antioxidants in drug therapeutics is still unresolved. This research topic aims to showcase the latest research regarding the mechanisms of redox homeostasis alongside the development of human diseases. An additional goal of this research topic is to discover new redox-regulatory drugs for human disease therapy via a new understanding of redox homeostasis. The third aim is to investigate new mechanisms with clinically available drugs to treat human diseases by mediating oxidative homeostasis. Finally, this research topic will improve redox-regulatory drug therapeutics by understanding the limitations of targeting oxidative stress and utilizing new drug therapeutic strategies.

With this research topic, we welcome original research and review, including effects and mechanisms of modulating redox homeostasis in the treatment of human disease. Details show below:

• Identification of new targets and mechanisms for regulation of redox homeostasis.
• Experimental and translational research of redox-regulatory drugs in human diseases including cancer, ischemic trauma, neurodegenerative, cardiovascular, metabolic, infection, Gastrointestinal and inflammatory diseases.
• Discovery of novel redox-regulatory drugs containing chemically synthetic small molecules, biopharmaceuticals, or natural compounds through the high-throughput screen, computational biology, medicinal chemistry, etc.
• Novel pharmacodynamic and pharmacokinetic mechanisms that are involved in redox homeostasis of currently used drugs in other aspects of treatment.

This research topic invites original research studies on synthetic and natural compounds, non-coding RNA, polypeptides, and therapeutic antibodies, please note that research studied on crude extracts or polyherbal preparations will not be accepted. Please note that research studies solely based on computer technology and network analysis without function/mechanism validation are not eligible for review.

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Frontiers in Pharmacology

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