About this Research Topic
Pediatric immunohematology is a dynamic field marked by evolving challenges and opportunities. This research initiative aims to address two critical aspects: the hematological manifestations of Inborn Errors of Immunity (IEI) and the advancements in cellular therapies, including Hematopoietic Stem Cell Transplantation (HSCT) and Gene Therapy, for treating IEI.
The understanding of hematological manifestations in IEI remains a cornerstone of pediatric immunohematology. Exploring these manifestations is crucial for accurate diagnosis, effective management, and improved patient outcomes. Research articles, original studies, reviews, case series, and case reports investigating various hematological presentations in IEI, such as cytopenias, abnormal blood cell morphology, and dysregulated hematopoiesis, are encouraged.
Furthermore, this Research Topic emphasizes the paradigm shift brought about by cellular therapies in treating IEI. Hematopoietic Stem Cell Transplantation (HSCT) offers a curative approach for many IEI patients, while Gene Therapy holds promise in correcting genetic defects underlying IEI, offering potential long-term benefits. Publications exploring the efficacy, safety, and novel applications of HSCT and Gene Therapy in IEI management are highly sought-after.
The interdisciplinary nature of pediatric immunohematology necessitates collaboration between hematologists, immunologists, geneticists, and other healthcare professionals. Through this Research Topic, we aim to foster collaboration and knowledge exchange to address the multifaceted challenges in pediatric immunohematology. By advancing our understanding of hematological manifestations in IEI and exploring cutting-edge cellular therapies, we strive to improve diagnostic accuracy, refine treatment strategies, and ultimately enhance the quality of life for pediatric patients with immune disorders.
Contributions covering a wide range of topics within pediatric immunohematology, including but not limited to the molecular mechanisms of hematological abnormalities in IEI, clinical outcomes of cellular therapies, challenges in patient selection, and emerging gene-editing technologies, are welcome. Together, we aim to chart new paths in pediatric immunohematology research, translating discoveries into tangible benefits for children affected by immune disorders.
The understanding of hematological manifestations in IEI remains a cornerstone of pediatric immunohematology. Exploring these manifestations is crucial for accurate diagnosis, effective management, and improved patient outcomes. Research articles, original studies, reviews, case series, and case reports investigating various hematological presentations in IEI, such as cytopenias, abnormal blood cell morphology, and dysregulated hematopoiesis, are encouraged.
Furthermore, this Research Topic emphasizes the paradigm shift brought about by cellular therapies in treating IEI. Hematopoietic Stem Cell Transplantation (HSCT) offers a curative approach for many IEI patients, while Gene Therapy holds promise in correcting genetic defects underlying IEI, offering potential long-term benefits. Publications exploring the efficacy, safety, and novel applications of HSCT and Gene Therapy in IEI management are highly sought-after.
The interdisciplinary nature of pediatric immunohematology necessitates collaboration between hematologists, immunologists, geneticists, and other healthcare professionals. Through this Research Topic, we aim to foster collaboration and knowledge exchange to address the multifaceted challenges in pediatric immunohematology. By advancing our understanding of hematological manifestations in IEI and exploring cutting-edge cellular therapies, we strive to improve diagnostic accuracy, refine treatment strategies, and ultimately enhance the quality of life for pediatric patients with immune disorders.
Contributions covering a wide range of topics within pediatric immunohematology, including but not limited to the molecular mechanisms of hematological abnormalities in IEI, clinical outcomes of cellular therapies, challenges in patient selection, and emerging gene-editing technologies, are welcome. Together, we aim to chart new paths in pediatric immunohematology research, translating discoveries into tangible benefits for children affected by immune disorders.
Keywords: Pediatrics, Immunohematology, hematopoietic stem cell transplantation, gene therapy, autoimmune cytopenia, bone marrow failure, immune thrombocytopenic purpura, cellular therapies, lymphoproliferation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
