About this Research Topic
Using cancer organoids to guide clinical medication and personalized treatment is crucial for clinical studies. Currently, cancer organoids are widely used in preclinical trials to improve new drug success rates and reduce costs and risks. By combining cancer organoid genomics and transcriptomics, we can link gene expression with drug sensitivity and identify biomarkers for drug efficacy. Additionally, pairing cancer organoids with CRISPR/Cas9 technology helps explore cancer drug resistance mechanisms and develop better anti-tumor therapies. Organoids also hold promise for rare diseases without animal models, aiding in new drug development or repurposing existing drugs for cancer treatment. In summary, cancer organoids accelerate new drug development and precision medicine in cancer research.
In this Topic, we aim to gather and evaluate the latest studies on cancer organoids and drug screening, offering fresh insights into their application in cancer clinical trials. We invite submissions of Original Research articles, Perspectives, Opinions, Reviews, and Mini Reviews focusing on new advancements, including but not limited to the following topics:
• Cancer Organoids as Advanced Models for Drug Screening;
• Advances in Organoids for Cancer Modeling and Therapeutic Applications;
• Organoid Technology and Tumor Precision Medicine;
• Cancer Organoids-on-a-chip for Cancer Immunotherapy;
• Advancements in Organoids and Spatiotemporal Omics: Unveiling Mechanistic Insights and Targeted Therapies for Cancer;
• Organoids for Regenerative Medicine;
• Organoids as Model Systems for Human Development, Disease, and Clinical Applications.
We accept different article types including Mini-Reviews, Brief Research Reports, and Perspectives. A full list of accepted article types, including descriptions, can be found at this link.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
Keywords: organoids, cancer biology, drug screening, precision medicine, clinical trials, biomarkers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.