In recent years, more and more attention has been paid to the research of natural Marine peptides with medicinal effects. Marine polypeptides exhibit unique biological activities such as antibacterial, antioxidant, anti-inflammatory, lowering blood pressure, lowering blood sugar, anticancer, anti-fatigue, and ...
In recent years, more and more attention has been paid to the research of natural Marine peptides with medicinal effects. Marine polypeptides exhibit unique biological activities such as antibacterial, antioxidant, anti-inflammatory, lowering blood pressure, lowering blood sugar, anticancer, anti-fatigue, and immune regulation, etc. Those biological activities have been favored by most researchers and have been widely studied. The peptide isolated from the leg muscle of the sea crab (Charybdis natator) (LGLGAAVL, MW 713.5Da) demonstrates anti-inflammatory activity by acting on COX-2 in LPS-induced RAW264.7 macrophages. Sea bream hydrolyzed polypeptides (IPVDM and IPV) have shown the ability to inhibit DPP-IV regulation of blood glucose in vitro. Active blood pressure lowering peptides were isolated from Marine organisms such as red seaweed, chlorella, asparagus and wakame. Marine antimicrobial peptides can play an anti-osteoporosis role by regulating the osteogenic synthesis pathway. However, there are few studies on the role of Marine peptides in bone immune regulation and bone joint prevention and treatment. Studies on the correlation between the structure of Marine polypeptides and bone activity are rarely reported, and the exact mechanism of action and target cells/molecules are still unclear.
The purpose of this special issue is to screen and analyze the structure of Marine active peptides with bone immunomodulation and bone joint prevention and treatment, and to explore their molecular mechanisms. Submissions should comply with the following requirements and scope:
1. The active polypeptide under study must be extracted and purified from Marine organisms, and its structure must be clearly analyzed. It can be oligopeptides and polypeptides.
2. Active polypeptides from the ocean need to be shown to have an effect on bone immune regulation and bone joints, and the data obtained from in vitro experiments must be confirmed in animal tests.
3. Studies may include elucidating the mechanism of action of active peptides on bone immune regulation and bone and joint.
Keywords:
marine peptides, bone immunomodulation, bone joint
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.