About this Research Topic
In this context, next generation sequencing (NGS) facilitated diagnosis by expanding the spectrum of possibly involved genes, and resulted in newly described genotype-phenotype correlations. Recent research is directed towards a better understanding of disease pathogenesis, the recognition of more specific disease biomarkers, personalized treatment approaches and development of novel therapeutic targets.
This Research Topic aims to highlight new perspectives on these diseases. Authors are encouraged to address the following themes:
- New genetic variations;
- Pathogenicity of variants by functional studies;
- Dysregulation of the inflammasome and assess the role of cytokine and other mediator network disequilibrium;
- Translational, proteomic or microbiome alterations;
- Candidate biomarkers able to classify patients;
- Clinical spectrum and prognosis in association with biological disease characteristics;
- The socioeconomic and psychological impact of SAIDs;
- The response to treatment in association with clinical and biological patient characteristics;
- Newer therapeutic approaches.
The preparation of original research papers is encouraged. However, Clinical Trials, Systematic Reviews, Study Protocols, Brief Research Reports, Case Reports, Community Case Studies, Mini Reviews, and General Commentaries are also welcome.
Keywords: Systemic Autoinflammatory Diseases, SAIDs, Inflammation, inflammatory diseases, therapeutic approaches
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.