About this Research Topic
The goal of this Research Topic is to provide a forum to advance research on discovering key targets and pathways related to the regulation of immune dysregulation in the tumor microenvironment. In addition, the special section also welcomes the submission of manuscript that develop new tools to augment T cell antitumor function.
The scope of this Research Topic is to focus on the latest basic and clinical progress in cancer immunotherapy and to help to understand the obstacles to the success of cancer immunotherapy and mechanisms underlying immune suppression and T cell exhaustion in tumor microenvironment. We warmly welcome the research and review articles to describe the theory and technique advances in understanding T cell function regulation and developing more efficient TCR-T and CAR-T cell therapy.
• New immune subsets that mediate antitumor immunity
• Checkpoints that restrain the polarization and expansion of antitumor immune subsets
• T cell subsets in response to checkpoint blockade immunotherapy
• Stem-like CD8+ T cells in the microenvironment
• Pathways and mechanisms that expand antitumor stem-like CD8+ T cells
• Efficient and persistent TCR-T and CAR-T cells
• Tumor-associated macrophages
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: Tumor immune microenvironment, T cell exhaustion, Stem-like CD8+ T cells, Tumor-associated macrophages, Cancer immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.