About this Research Topic
Connexin-mediated intercellular communication involves bidirectional cell-to-cell coupling via gap junctions and the release or influx of molecules through hemichannels. Various channel-independent activities of connexins have been discovered. Currently, both the channel-dependent and independent functions of connexins hold significant relevance in various diseases, including cancer, congenital cataracts, depression, hereditary deafness, and congenital heart disease. Therefore, connexin mutations and/or differential gene/protein expression levels are potential biomarkers for diagnosis and prognosis of diseases. Different molecular approaches, such as mimetic peptides, connexin inhibitors, and antibodies, have been developed to target connexins.
This Research Topic invites submissions that highlight the latest advancements in the development of connexin-based biomarkers and connexin-targeting agents within clinical research settings. We welcome contributions that discuss the application of these biomarkers and agents across various disease contexts, shedding light on their potential diagnostic and therapeutic implications.
We welcome submissions of Brief Research Report, Clinical Trial, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, and Systematic Review. Topics of particular interest include, but are not limited to:
• Exploration of connexin-based biomarkers for disease diagnosis and prognosis.
• Evaluation of connexin-targeting agents in preclinical and clinical studies.
• Molecular mechanisms underlying connexin-targeting agents.
• Impact of connexin mutations on disease susceptibility and progression.
• Development of novel molecular strategies targeting connexins for therapeutic interventions.
• Connexin dysfunction in ocular diseases and potential therapeutic interventions.
• Connexin-based approaches for regenerative medicine and tissue engineering.
This Research Topic invites submissions that highlight the latest advancements in the development of connexin-based biomarkers and connexin-targeting agents within clinical research settings. We welcome contributions that discuss the application of these biomarkers and agents across various disease contexts, shedding light on their potential diagnostic and therapeutic implications.
We welcome submissions of Brief Research Report, Clinical Trial, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, and Systematic Review. Topics of particular interest include, but are not limited to:
• Exploration of connexin-based biomarkers for disease diagnosis and prognosis.
• Evaluation of connexin-targeting agents in preclinical and clinical studies.
• Molecular mechanisms underlying connexin-targeting agents.
• Impact of connexin mutations on disease susceptibility and progression.
• Development of novel molecular strategies targeting connexins for therapeutic interventions.
• Connexin dysfunction in ocular diseases and potential therapeutic interventions.
• Connexin-based approaches for regenerative medicine and tissue engineering.
Keywords: Connexins, Diseases, Therapy, Diagnostic, Gap Junctions
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
