About this Research Topic
Research into amyotrophic lateral sclerosis (ALS) is of paramount importance due to the severe and progressive nature of ALS, a neurodegenerative disorder that affects motor neurons. This Research Topic explores crucial pathways implicated in the disease, shedding light on the underlying molecular mechanisms. Understanding these pathways is vital for developing targeted therapeutic interventions and potential treatments for ALS. Additionally, insights gained from the research contribute to advancing the overall knowledge of neurodegenerative disorders and may pave the way for innovative strategies to improve the quality of life for individuals affected by ALS. In essence, this collection serves as a cornerstone for researchers, clinicians, and healthcare professionals striving to unravel the complexities of ALS and discover transformative approaches for its management
In this Research Topic, we welcome articles that explore the intricate interplay between various cellular and molecular pathways implicated in ALS pathogenesis, investigating the role of genetic mutations, protein misfolding, oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired protein clearance pathway. Additionally, we welcome articles on the development and preclinical testing of novel therapeutic agents, including gene therapies, small molecules, and biologics, with the goal of slowing or halting disease progression. We also welcome articles that examine the impact of environmental factors, lifestyle interventions, and patient care approaches on ALS outcomes, with the aim of improving patient quality of life and prognosis. Overall, this collection seeks to advance our understanding of ALS and facilitate the translation of research findings into tangible clinical benefits for patients and their families.
We welcome a variety of article types, including under the following categories: Original Research, Review, Mini Review, Brief Research Report, and Perspective.
In this Research Topic, we welcome articles that explore the intricate interplay between various cellular and molecular pathways implicated in ALS pathogenesis, investigating the role of genetic mutations, protein misfolding, oxidative stress, neuroinflammation, mitochondrial dysfunction, and impaired protein clearance pathway. Additionally, we welcome articles on the development and preclinical testing of novel therapeutic agents, including gene therapies, small molecules, and biologics, with the goal of slowing or halting disease progression. We also welcome articles that examine the impact of environmental factors, lifestyle interventions, and patient care approaches on ALS outcomes, with the aim of improving patient quality of life and prognosis. Overall, this collection seeks to advance our understanding of ALS and facilitate the translation of research findings into tangible clinical benefits for patients and their families.
We welcome a variety of article types, including under the following categories: Original Research, Review, Mini Review, Brief Research Report, and Perspective.
Keywords: Amyotrophic Lateral Sclerosis, ALS, Protein Misfolding, Oxidative Stress, Mitochondrial Dysfunction
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
