The combination of advanced cell culture methods and novel miniaturized sensor platforms in various formats has opened up a research landscape for studying mammalian cell responses. Real-time analysis of changes in cell metabolic status is possible by monitoring oxygen consumption, proton/pH changes, and ATP production in commercially available systems. Other approaches have measured the depletion or production of nutrients or metabolites over time. These types of sensor systems offer the possibility for medical or environmental toxicity testing of samples on well-characterized cell lines, spheroids, or indeed primary cells. Other applications include testing therapeutic drugs against patient cells for efficacy before in-vivo use, as well as numerous novel research studies.
The power of cell sensing can be enhanced by using a variety of surface materials modified with specific biorecognition elements to enable the capture of specific cell types for analysis. This has the potential to not only to phenotype a cell population, but to interrogate cell metabolism and/or response upon stimulation, both at a single-cell level and using multiple sensor arrays. For example, by combining immune cell capture, stimulation, and signal output, there is the potential to examine the cellular immune response in clinical diseases.
Numerous combinations of biorecognition elements (antibodies, aptamers, receptors, MHC + peptides, tetramers, nucleic acids, nanomaterials) and modes of signal transduction (optical, electrochemical, impedance, piezoelectric, magnetic, physical, etc.) are possible. Sensor configurations in a lab-on-chip format, including microfluidic systems, are at the forefront of this research.
The aim of this Frontiers article collection is to cover the latest research in developing or applying sensor technologies for all types of mammalian cell detection and monitoring.
We welcome the submission of Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to:
• Sensors for monitoring mammalian cell viability and metabolism
• Sensors for mammalian cell selective recognition, capture, and characterization
• Sensors for biomarkers associated with biophysical mechanisms in mammalian cells
• Single- or multiple-cells sensors/arrays
• Electrochemical, optical, impedance, piezoelectric, magnetic, physical sensors
• Applications including medical diagnostics, immune function, toxin detection
Keywords:
mammalian cell, biorecognition, capture, functional analysis, sensors, biosensors
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The combination of advanced cell culture methods and novel miniaturized sensor platforms in various formats has opened up a research landscape for studying mammalian cell responses. Real-time analysis of changes in cell metabolic status is possible by monitoring oxygen consumption, proton/pH changes, and ATP production in commercially available systems. Other approaches have measured the depletion or production of nutrients or metabolites over time. These types of sensor systems offer the possibility for medical or environmental toxicity testing of samples on well-characterized cell lines, spheroids, or indeed primary cells. Other applications include testing therapeutic drugs against patient cells for efficacy before in-vivo use, as well as numerous novel research studies.
The power of cell sensing can be enhanced by using a variety of surface materials modified with specific biorecognition elements to enable the capture of specific cell types for analysis. This has the potential to not only to phenotype a cell population, but to interrogate cell metabolism and/or response upon stimulation, both at a single-cell level and using multiple sensor arrays. For example, by combining immune cell capture, stimulation, and signal output, there is the potential to examine the cellular immune response in clinical diseases.
Numerous combinations of biorecognition elements (antibodies, aptamers, receptors, MHC + peptides, tetramers, nucleic acids, nanomaterials) and modes of signal transduction (optical, electrochemical, impedance, piezoelectric, magnetic, physical, etc.) are possible. Sensor configurations in a lab-on-chip format, including microfluidic systems, are at the forefront of this research.
The aim of this Frontiers article collection is to cover the latest research in developing or applying sensor technologies for all types of mammalian cell detection and monitoring.
We welcome the submission of Original Research, Review, Mini Review, and Perspective articles on themes including, but not limited to:
• Sensors for monitoring mammalian cell viability and metabolism
• Sensors for mammalian cell selective recognition, capture, and characterization
• Sensors for biomarkers associated with biophysical mechanisms in mammalian cells
• Single- or multiple-cells sensors/arrays
• Electrochemical, optical, impedance, piezoelectric, magnetic, physical sensors
• Applications including medical diagnostics, immune function, toxin detection
Keywords:
mammalian cell, biorecognition, capture, functional analysis, sensors, biosensors
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.