Since the beginning of COVID-19 pandemics, more than 700 million people (nearly 10% of world population) have been diagnosed with COVID-19. It has changed the world and medical community tremendously in a way that we had not expected in short period of time. COVID-19 is a systemic disease that not only affects respiratory systems but also other organs. Kidney is one of the major organs that is impacted by COVID-19 leading morbidity and mortality. In the early days of pandemic, approximately 30-40% of COVID-19 patients developed acute kidney injury and renal replacement therapy ensued in many of them. Several mechanisms involving kidney injury in COVID-19 patients include but not limited to direct cellular injury from the virus or indirect effects such as hemodynamic changes, hyper inflammatory state, immune dysregulation, drugs toxicities and etc. COVID-19 vaccination has been one of important strategies to curb the infection and the first FDA-approved mRNA vaccine in the clinical settings has been implemented in large scale vaccination programs. Despite its efficacy in preventing infection, some potential kidney complications have emerged.

The aim of this “Research Topic” is to highlight the important link between COVID-19, COVID-19 vaccination and kidney diseases. We aim to explore current data and recent advancement COVID-19 and COVID-19 vaccination on kidneys in the following area:

1. Characteristics, outcome and impacts of acute kidney injury, acute kidney disease and chronic kidney disease in COVID-19 and COVID-19 vaccinations

2. Glomerular and interstitial disease associated with COVID-19 and COVID-19 vaccinations

3. Current diagnostic, therapeutic and prognostic approaches in kidney diseases in COVID-19 and COVID-19 vaccinations

4. Long COVID and kidneys outcomes

5. Health disparities in COVID-19 and kidney diseases

6. Immunosuppression modifications in kidney disease patients with COVID-19

7. Electrolyte abnormalities associated with COVID 19

These items, though not limited to, are the key topics that we primarily focus in this special issue.

We value diversity and thus would seek papers from all around the world in order to better understand the global practice. We welcome all form of manuscript that would fulfil our missions and goals which include:

- Original Research

- Clinical Trials

- Systematic Review

- Review

- Mini Review

- Case Report

- Perspective

- Brief Research Report

- Policy and Practice Reviews

- Policy Brief

- Hypothesis & Theory

- Study Protocol

- Methods

- Data Report

- General Commentary

- Opinion

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Frontiers in Nephrology

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