About this Research Topic
Immunotherapy, an innovative approach to cancer treatment, has exhibited encouraging preliminary results. It enhances the overall survival rates among patients afflicted with various solid tumors, such as melanoma, and can activate the immune system in select individuals. Nevertheless, several obstacles persist within the realm of immunotherapy, including issues related to drug resistance and suboptimal treatment responses. Combinatorial immunotherapeutic strategies are thus poised to emerge as the most promising approach for enhancing patient responses and overall treatment outcomes. These strategies encompass the potential integration of synergistic combinations of immunotherapeutic agents or the concurrent utilization of immunotherapeutic agents alongside conventional oncological modalities, including radiotherapy and targeted therapy, to achieve optimal therapeutic effects.
Transcriptome analysis and single-cell sequencing analysis represent burgeoning methodologies, adept at scrutinizing the gene expression profiles of individual cells within tissues. These techniques are instrumental in investigating inter-cellular heterogeneity, demarcating distinct cell types and subtypes, elucidating cell type-specific gene signatures, and unveiling the dynamic processes occurring within cells in the process of combination therapy with immunotherapy.
This Research Topic is to investigate the intricate immune microenvironment within cancer for patients receiving immunotherapy or immunotherapy-based combination therapy by employing transcriptome analysis and single-cell sequencing methodologies. Our aim is to gain a comprehensive understanding of the potential mechanisms and intervention points that influence the emergence of “hot” and “cold” tumors to enhance the prognosis of cancer immunotherapies. Through these endeavors, our goal is to provide valuable insights and empirical data that will inform the development of precise therapeutic interventions for cancer.
Researchers are encouraged to submit Original Research articles, Reviews, Mini-reviews, Systematic Reviews, Case Reports, Perspectives, Short communications, Opinions, Study Protocols, and Methods relevant to this article collection that will cover topics such as (but not limited to):
Utilizing transcriptome analysis, single-cell sequencing, and other high-throughput methodologies to identify distinct immunological subtypes of cancer.
Conducting transcriptome and single-cell sequencing studies to discover novel cancer prognostic markers, associated prognostic signatures, and to predict responses to immunotherapy.
Investigating the carcinogenic potential of environmental disruptors, their adverse effects on the human immune system, and their interactions with cancer immunity.
Employing single-cell sequencing and spatial transcriptome analysis to elucidate the spatial localization relationships between cells and to explore the underlying immune mechanisms within tumors.
Transcriptome analysis and single-cell sequencing analysis represent burgeoning methodologies, adept at scrutinizing the gene expression profiles of individual cells within tissues. These techniques are instrumental in investigating inter-cellular heterogeneity, demarcating distinct cell types and subtypes, elucidating cell type-specific gene signatures, and unveiling the dynamic processes occurring within cells in the process of combination therapy with immunotherapy.
This Research Topic is to investigate the intricate immune microenvironment within cancer for patients receiving immunotherapy or immunotherapy-based combination therapy by employing transcriptome analysis and single-cell sequencing methodologies. Our aim is to gain a comprehensive understanding of the potential mechanisms and intervention points that influence the emergence of “hot” and “cold” tumors to enhance the prognosis of cancer immunotherapies. Through these endeavors, our goal is to provide valuable insights and empirical data that will inform the development of precise therapeutic interventions for cancer.
Researchers are encouraged to submit Original Research articles, Reviews, Mini-reviews, Systematic Reviews, Case Reports, Perspectives, Short communications, Opinions, Study Protocols, and Methods relevant to this article collection that will cover topics such as (but not limited to):
Utilizing transcriptome analysis, single-cell sequencing, and other high-throughput methodologies to identify distinct immunological subtypes of cancer.
Conducting transcriptome and single-cell sequencing studies to discover novel cancer prognostic markers, associated prognostic signatures, and to predict responses to immunotherapy.
Investigating the carcinogenic potential of environmental disruptors, their adverse effects on the human immune system, and their interactions with cancer immunity.
Employing single-cell sequencing and spatial transcriptome analysis to elucidate the spatial localization relationships between cells and to explore the underlying immune mechanisms within tumors.
Keywords: Immunotherapy, Transcriptome analysis, Single-cell sequencing analysis, Tumor microenvironment, Combination Treatments
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
