About this Research Topic
RNA modifications, such as pseudouridine (Ψ) and N6-methyladenosine (m6A), have been extensively studied. Over 170 types of RNA modifications have been characterized, with m6A being the most abundant and well-characterized modification in eukaryotic mRNA. It plays a dynamic and reversible role in regulating RNA metabolism and impacting various biological processes. In addition to m6A, other non-m6A modifications include Ψ, N1-methyladenosine (m1A), 5-methylcytidine (m5C), N6,2′-Odimethyladenosine (m6Am), inosine, N4-acetylcytidine (ac4C), 2′-O-methylated nucleotide (Nm), and internal N7-methylguanosine (m7G). These modifications have been shown to have diverse functions in gene expression and human diseases. Understanding their biosynthesis, distribution, regulation, and function will contribute to a comprehensive perspective on epitranscriptomics research and advance RNA biology. While these modifications have garnered attention, many aspects of their functional mechanisms and regulatory roles remain unknown, hindering deeper exploration.
The main issue we aim to address in this Research Topic is the role of Non-m6A mRNA modifications in tumors and how they contribute to tumorigenesis, tumor progression, and therapeutic resistance. The central objective is to gain a more accurate understanding of the regulatory mechanisms, modification landscape, and roles of Non-m6A mRNA modifications in physiological and pathological conditions, in order to explore their regulatory effects and biological significance. To achieve this, we aim to compile a wide range of interdisciplinary research, investigating the functional mechanisms of Non-m6A mRNA modifications and conducting comparative and multi-layered analyses of therapeutic approaches based on Non-m6A mRNA modifications, including antisense oligonucleotides, RNA aptamers, short interfering RNA drugs, as well as drugs utilizing or targeting endogenous mRNA modifications or related enzymes. We also aim to integrate studies from various fields, including basic and clinical immunology, oncology, and virology/microbiology.
We welcome the submission of Original Research, Review, Mini-Review, Methods, Case report, and Perspective articles that cover, but are not limited to, the following topics:
• Regulatory mechanisms of Non-m6A mRNA modifications
• Study of modification landscape
• Impact of modifications on biological functions
• Therapeutic approaches based on Non-m6A mRNA modifications
• The function of Non-m6A mRNA modifications and the relevance of different target sites.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
The main issue we aim to address in this Research Topic is the role of Non-m6A mRNA modifications in tumors and how they contribute to tumorigenesis, tumor progression, and therapeutic resistance. The central objective is to gain a more accurate understanding of the regulatory mechanisms, modification landscape, and roles of Non-m6A mRNA modifications in physiological and pathological conditions, in order to explore their regulatory effects and biological significance. To achieve this, we aim to compile a wide range of interdisciplinary research, investigating the functional mechanisms of Non-m6A mRNA modifications and conducting comparative and multi-layered analyses of therapeutic approaches based on Non-m6A mRNA modifications, including antisense oligonucleotides, RNA aptamers, short interfering RNA drugs, as well as drugs utilizing or targeting endogenous mRNA modifications or related enzymes. We also aim to integrate studies from various fields, including basic and clinical immunology, oncology, and virology/microbiology.
We welcome the submission of Original Research, Review, Mini-Review, Methods, Case report, and Perspective articles that cover, but are not limited to, the following topics:
• Regulatory mechanisms of Non-m6A mRNA modifications
• Study of modification landscape
• Impact of modifications on biological functions
• Therapeutic approaches based on Non-m6A mRNA modifications
• The function of Non-m6A mRNA modifications and the relevance of different target sites.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: non-m6A mRNA modifications, tumors, functional mechanisms, therapeutic approaches, Ψ, N1-methyladenosine, 5-methylcytidine, N6, 2′-Odimethyladenosine, inosine, N4-acetylcytidine, 2′-O-methylated nucleotide, internal N7-methylguanosine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
