Human aging is a complicated physiological process that is followed by the emergence of aging-related disorders such as cancer, infection, autoimmune diseases, type II diabetes, cardiovascular, and cerebrovascular diseases. In recent years, scholars have noticed the relationship between immunity and aging and proposed the immune theory of aging, which proposes that immune decline is one of the main pathogenic factors of aging and that the immune system decline weakens the body's resistance to tumors and pathogens while increasing the risk of autoimmunity and causing chronic inflammation. "Immune senescence" is turning into a hot keyword. It seems like immunological senescence differs from aging. The pathophysiology, causal link with aging and disease, and biomarkers of immunological senescent cells are all fascinating subjects.

Immunosenescence is a process of immune dysfunction that occurs with age and includes remodeling of lymphoid organs, leading to changes in the immune function of the elderly. This is closely related to the development of infections, autoimmune diseases, and malignant tumors. Recent findings in the field show that one of the most harmful subtypes of senescent cells are senescent immune cells, which hasten the aging of solid organs and thus foster systemic senescence. Senescent immune cells have so emerged as a crucial target for reducing the rate of aging. It's anticipated that immune cells will one day allow us to slow down the aging process.

The current Research Topic aims to cover promising, recent, and novel research trends in the immunosenescence field. Clinical investigations, such as clinical-level validation of the association between immune senescence and tumor incidence, as well as the relationship between different levels of immunological senescence and the occurrence of malignancies and disorders in older adults, are prioritized. New technologies such as Integrating single-cell and spatial transcriptomics are welcomed to figure out the biomarkers of immune senescence cells.

We welcome submissions in the form of original research, reviews, mini-reviews, clinical trials, and case reports, that cover (but are not limited) to the following topics:

•Identify the phenotype of immunosenescence
•Immune senescence's upstream pathogenesis
•The cause-and-effect connection between immunological senescence and the body’s systemic senescence
•The impact of delaying immune senescence of the body
•The therapeutic method to delay immune cells' senescence

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Frontiers in Aging

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