Psychiatric and mental disorders exert a substantial and widespread impact on global health. The prevalence of these disorders is noteworthy, with an estimated 1 in 3000 individuals affected by schizophrenia and 5 out of 100 individuals experiencing depression. Additionally, approximately 2% of the population suffers from some type of addiction. Notably, the COVID-19 pandemic has accentuated these mental diseases. Globally, 1 in 8 people is currently living with a mental disorder. These statistics collectively underscore the profound implications that psychiatric disorders have on both individual well-being and the broader global economy. The ongoing public health crisis has further emphasized the importance of addressing and understanding mental health as an integral component of overall health and well-being.
The objective of this Research Topic is to unravel and integrate molecular mechanisms associated with the onset of psychiatric disorders. These mechanisms could include inflammatory and oxidative stress processes, immune dysregulation, neuroplasticity modulation, or microbiome disbalances. Recent findings suggest that drugs with anti-inflammatory and antioxidant properties may augment the beneficial effects of antipsychotics and antidepressants in patients with schizophrenia and depression, respectively. Furthermore, the administration of probiotics, aimed at modulating microbiome imbalances, has demonstrated effectiveness in alleviating certain symptoms in individuals with depression. This Research Topic seeks to deepen our understanding of these molecular pathways to explore novel therapeutic interventions that extend beyond traditional pharmacological approaches.
In this context, contributions from both preclinical and clinical studies are encouraged. The disorders of interest include, but are not limited to, schizophrenia, depression, bipolar disorders, autism and addictions. Furthermore, meta-analyses or reviews that compile robust evidence on this Research Topic will also be of significant interest, furthering our understanding of these disorders.
Keywords:
Molecular mechanisms, Schizophrenia, Depression, Addictions, Psychiatry, Microbiome, Inflammation, Oxidative Stress
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Psychiatric and mental disorders exert a substantial and widespread impact on global health. The prevalence of these disorders is noteworthy, with an estimated 1 in 3000 individuals affected by schizophrenia and 5 out of 100 individuals experiencing depression. Additionally, approximately 2% of the population suffers from some type of addiction. Notably, the COVID-19 pandemic has accentuated these mental diseases. Globally, 1 in 8 people is currently living with a mental disorder. These statistics collectively underscore the profound implications that psychiatric disorders have on both individual well-being and the broader global economy. The ongoing public health crisis has further emphasized the importance of addressing and understanding mental health as an integral component of overall health and well-being.
The objective of this Research Topic is to unravel and integrate molecular mechanisms associated with the onset of psychiatric disorders. These mechanisms could include inflammatory and oxidative stress processes, immune dysregulation, neuroplasticity modulation, or microbiome disbalances. Recent findings suggest that drugs with anti-inflammatory and antioxidant properties may augment the beneficial effects of antipsychotics and antidepressants in patients with schizophrenia and depression, respectively. Furthermore, the administration of probiotics, aimed at modulating microbiome imbalances, has demonstrated effectiveness in alleviating certain symptoms in individuals with depression. This Research Topic seeks to deepen our understanding of these molecular pathways to explore novel therapeutic interventions that extend beyond traditional pharmacological approaches.
In this context, contributions from both preclinical and clinical studies are encouraged. The disorders of interest include, but are not limited to, schizophrenia, depression, bipolar disorders, autism and addictions. Furthermore, meta-analyses or reviews that compile robust evidence on this Research Topic will also be of significant interest, furthering our understanding of these disorders.
Keywords:
Molecular mechanisms, Schizophrenia, Depression, Addictions, Psychiatry, Microbiome, Inflammation, Oxidative Stress
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.