About this Research Topic
Mild and asymptomatic thrombocytopenia may be incidentally detected within the course of several diseases including infections, autoimmune disorders, malignancies and liver diseases. Severe thrombocytopenia may lead to life-threatening bleeding but also, in some specific conditions, to thrombotic complications.
There are currently no specific tests to diagnose primary immune thrombocytopenia (ITP) and many cases of thrombocytopenia are, often later, found to be misdiagnosed as ITP, as suggested by recently launched registries. Several studies report that a vast majority of misdiagnosed ITP are thrombocytopenias secondary to autoimmune diseases, immunodeficiency, and drug reactions.
Thrombocytopenia should be carefully evaluated for its potential implications in the management of autoimmune disorders like antiphospholipid syndromes. Up to date the differential diagnosis between primary immune thrombocytopenia (ITP) and secondary thrombocytopenias is not always easy or immediate.
A key focus of this Research Topic is to highlight the wide spectrum of thrombocytopenias and their immune component as part of several disorders. The differential diagnosis between primary and secondary thrombocytopenias requires an accurate approach, as it may affect treatment choices and influence clinical outcomes in an aging population; the need for concomitant treatments for comorbidities or underlying disease complications amplifies the crucial role of this issue.
The aim of the Research Topic is to describe the mechanisms behind primary immune thrombocytopenias and secondary thrombocytopenias to support clinicians in defining the most appropriate diagnostic workup and treatment strategies in each scenario.
This Research Topic is mainly focused on the immune components of different types of thrombocytopenias - we will accept biological and clinical original studies, as well as reviews focused on diagnosis, clinical course, and management of thrombocytopenia in hematology, oncology, infectious diseases, and autoimmune disorders. Case reports of particular interest will be also evaluated for publication.
There are currently no specific tests to diagnose primary immune thrombocytopenia (ITP) and many cases of thrombocytopenia are, often later, found to be misdiagnosed as ITP, as suggested by recently launched registries. Several studies report that a vast majority of misdiagnosed ITP are thrombocytopenias secondary to autoimmune diseases, immunodeficiency, and drug reactions.
Thrombocytopenia should be carefully evaluated for its potential implications in the management of autoimmune disorders like antiphospholipid syndromes. Up to date the differential diagnosis between primary immune thrombocytopenia (ITP) and secondary thrombocytopenias is not always easy or immediate.
A key focus of this Research Topic is to highlight the wide spectrum of thrombocytopenias and their immune component as part of several disorders. The differential diagnosis between primary and secondary thrombocytopenias requires an accurate approach, as it may affect treatment choices and influence clinical outcomes in an aging population; the need for concomitant treatments for comorbidities or underlying disease complications amplifies the crucial role of this issue.
The aim of the Research Topic is to describe the mechanisms behind primary immune thrombocytopenias and secondary thrombocytopenias to support clinicians in defining the most appropriate diagnostic workup and treatment strategies in each scenario.
This Research Topic is mainly focused on the immune components of different types of thrombocytopenias - we will accept biological and clinical original studies, as well as reviews focused on diagnosis, clinical course, and management of thrombocytopenia in hematology, oncology, infectious diseases, and autoimmune disorders. Case reports of particular interest will be also evaluated for publication.
Keywords: thrombocytopenia, immune thrombocytopenia, infections, autoimmune disease, cancer, hematological malignancies
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