About this Research Topic
Rapidly developing sequencing technology, lower sequencing costs, and novel approaches across the -omic disciplines are allowing us to look with unprecedented detail at the physiological and molecular mechanisms of brain health and disease. The implementation of telomere-to-telomere sequencing and pan-omics for the study of human variability has just started, but the promise of elucidating the intricacies of neurodegeneration, psycho-behavioral conditions, and disorders of brain development is incredibly real and tangible. This new wave of discovery has been also prompted by the renewed interest toward brain evolution, epigenetics, and the re-evaluation of the previously undervalued mobile genome in mediating protein expression in the neuron.
Inflammation, aging, infection, pollution, nutrition, and the gut-brain axis are also heavily involved in the health of the central and peripheral nervous system. In addition, gene (as well as protein) network alteration stimulated by these drivers has been pinned as a cause for altered brain functions that may manifest themselves through behavioral and psychological symptoms. Finally, associations between gene/protein variants, altered metabolic parameters, and structural alterations picked up by neuroimaging techniques reveal the complex interactions between different levels of inquiry in this exciting field. This requires the development of new statistical methodologies and advanced bioinformatics tools to tackle the huge amount of data coming from different sources, which provide an integrated look into brain health and disease.
This Research Topic aims to include a broad range of studies and disciplinary outlooks on brain health and disease. We particularly encourage contributions related to research around the functional, evolutionary, molecular, and genetic aspects of this topic, with attention to statistical and methodological novelty and a keen interest in multidisciplinary, interdisciplinary, and translational approaches to innovative and cutting-edge research questions in brain health and disease.
Inflammation, aging, infection, pollution, nutrition, and the gut-brain axis are also heavily involved in the health of the central and peripheral nervous system. In addition, gene (as well as protein) network alteration stimulated by these drivers has been pinned as a cause for altered brain functions that may manifest themselves through behavioral and psychological symptoms. Finally, associations between gene/protein variants, altered metabolic parameters, and structural alterations picked up by neuroimaging techniques reveal the complex interactions between different levels of inquiry in this exciting field. This requires the development of new statistical methodologies and advanced bioinformatics tools to tackle the huge amount of data coming from different sources, which provide an integrated look into brain health and disease.
This Research Topic aims to include a broad range of studies and disciplinary outlooks on brain health and disease. We particularly encourage contributions related to research around the functional, evolutionary, molecular, and genetic aspects of this topic, with attention to statistical and methodological novelty and a keen interest in multidisciplinary, interdisciplinary, and translational approaches to innovative and cutting-edge research questions in brain health and disease.
Keywords: Omics, Integrative Methods, Translational approaches, Brain Health, Disease
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