About this Research Topic
Exploring the complex cellular interactions and molecular responses in immune cells that are triggered by HbS polymerization will provide novel pathophysiological insights and guide the development of more effective therapeutic strategies for modifying the clinical course of sickle cell disease.
This Research Topic aims to publish high-quality original research that highlights the interplay between inflammatory and immunological pathways in the pathogenesis of sickle cell disease. We welcome submissions focusing on, but not limited to:
• Characterization of inflammatory cells, cytokines, biomarkers and DAMPs in SCD
• Thromboinflammation and complement system activation in SCD
• Endothelial cell activation and dysfunction in SCD
• Roles of immune cell extracellular traps (NETs, EETs) in SCD pathophysiology
• Role of intravascular hemolysis in innate immune and inflammatory responses in SCD
• Role of hypoxia-reperfusion processes and oxidative stress in SCD pathophysiology
• Role of microbiota and intestinal permeability in sickle SCD pathophysiology
• Immunopathogenesis of vaso-occlusion
• Targeting inflammation/ immunity for the treatment and reversal of painful vaso-occlusive crisis
• Inflammasomes and SCD pathophysiology
• Targeting inflammation/ innate immune responses for preventing end-organ damage in SCD.
• Resolution of inflammation in SCD
• Hemopoietic stem cell transplantation and inflammatory responses in SCD
• Translational and clinical studies targeting inflammation and innate immune responses in patients with SCD
• Novel therapeutic targets in SCD
Nicola Conran is employed by the State University of Campinas. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Keywords: Cellular adhesion, Cytokine, inflammasome, leukocytes, platelets, vascular inflammation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.