About this Research Topic
Frontiers in Aging is delighted to announce a new Research Topic dedicated to unraveling the mysteries of aging through the lens of stem cell biology. As our global population continues to age, understanding the fundamental processes underlying the aging phenomenon is crucial to developing interventions and therapeutics for age-related diseases.
This Research Topic aims to shed light on the intricate interplay between stem cells and aging, exploring the multifaceted roles of stem cells in tissue rejuvenation, regeneration, and age-related pathology. We invite leading researchers, clinicians, and experts in the field to contribute their original research, reviews, and perspectives.
Topics of interest include, but are not limited to:
• Stem cell dynamics and their changes during aging.
• Cellular senescence and its impact on stem cell function (telomere shortening, P53 pathways signaling, senescence associated secretory phenotype (SASPs)).
• Stem cell niches and their role in tissue homeostasis and regeneration.
• Epigenetic regulation of stem cell aging.
• Stem cell-based therapies for age-related diseases.
• Age-related changes in stem cell differentiation and plasticity.
• Rejuvenation strategies for aged stem cells.
• Proteostasis: protein homeostasis in aging stem cells, including the effects of misfolded proteins, autophagy, and the ubiquitin-proteasome system.
• Cellular metabolism: Impact of changes in metabolism, such as mitochondrial dysfunction and altered nutrient sensing pathways (e.g., mTOR, AMPK, SIRT1), on stem cell function and tissue regeneration.
• Inflammation and immune system interaction: Chronic inflammation and immune system changes on stem cell function and regenerative capacity, including the role of cytokines and immune cells.
• Systemic factors and interventions: hormones and circulating proteins, influence stem cell aging and tissue regeneration.
• Bioinformatics and computational modelling: bioinformatics and computational approaches leveraging (public) big data/ repositories from genomics, proteomics, and metabolomics studies related to stem cell aging and regeneration.
This article collection provides a platform for scientists to showcase their cutting-edge research, present novel findings, and share expert opinions on the potential of stem cell-based approaches in combating age-related decline. By uniting the efforts of researchers and practitioners in this field, we aim to pave the way for innovative therapies and interventions that can improve the quality of life for the aging population.
We encourage all researchers working in the field of stem cell biology and aging to contribute their work. Together we can embark on a journey to uncover the secrets of aging and harness the regenerative potential of stem cells to promote healthy aging and longevity.
This Research Topic aims to shed light on the intricate interplay between stem cells and aging, exploring the multifaceted roles of stem cells in tissue rejuvenation, regeneration, and age-related pathology. We invite leading researchers, clinicians, and experts in the field to contribute their original research, reviews, and perspectives.
Topics of interest include, but are not limited to:
• Stem cell dynamics and their changes during aging.
• Cellular senescence and its impact on stem cell function (telomere shortening, P53 pathways signaling, senescence associated secretory phenotype (SASPs)).
• Stem cell niches and their role in tissue homeostasis and regeneration.
• Epigenetic regulation of stem cell aging.
• Stem cell-based therapies for age-related diseases.
• Age-related changes in stem cell differentiation and plasticity.
• Rejuvenation strategies for aged stem cells.
• Proteostasis: protein homeostasis in aging stem cells, including the effects of misfolded proteins, autophagy, and the ubiquitin-proteasome system.
• Cellular metabolism: Impact of changes in metabolism, such as mitochondrial dysfunction and altered nutrient sensing pathways (e.g., mTOR, AMPK, SIRT1), on stem cell function and tissue regeneration.
• Inflammation and immune system interaction: Chronic inflammation and immune system changes on stem cell function and regenerative capacity, including the role of cytokines and immune cells.
• Systemic factors and interventions: hormones and circulating proteins, influence stem cell aging and tissue regeneration.
• Bioinformatics and computational modelling: bioinformatics and computational approaches leveraging (public) big data/ repositories from genomics, proteomics, and metabolomics studies related to stem cell aging and regeneration.
This article collection provides a platform for scientists to showcase their cutting-edge research, present novel findings, and share expert opinions on the potential of stem cell-based approaches in combating age-related decline. By uniting the efforts of researchers and practitioners in this field, we aim to pave the way for innovative therapies and interventions that can improve the quality of life for the aging population.
We encourage all researchers working in the field of stem cell biology and aging to contribute their work. Together we can embark on a journey to uncover the secrets of aging and harness the regenerative potential of stem cells to promote healthy aging and longevity.
Keywords: stem cells, aging, interventions, therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
