Aging, Cellular Senescence in Bone and Joint Diseases

The field of aging and cellular senescence in bone and joint diseases is gaining increasing attention due to its significant impact on human health and mobility. As individuals age, the bone and joint system undergoes various degenerative changes, leading to conditions such as osteoporosis, osteoarthritis, and intervertebral disc degeneration. These changes are primarily driven by the accumulation of senescent cells, which are characterized by irreversible cell cycle arrest and distinct cellular alterations. Recent studies have highlighted the role of cellular senescence in the progression of age-related bone and joint diseases, emphasizing the need for a deeper understanding of the underlying mechanisms. Despite advancements in identifying the role of senescent cells, there remains a gap in translating this knowledge into effective therapeutic interventions. Current research is focused on developing senolytic and rejuvenescence drugs that target senescent cells, offering promising prospects for treating bone and joint degeneration. However, further investigation is required to fully elucidate the complex interactions between aging, cellular senescence, and bone and joint health.

This research topic aims to explore the intricate relationship between aging, cellular senescence, and bone and joint diseases. The primary objective is to uncover novel mechanisms and pathways involved in the senescence process and their impact on bone and joint health. By addressing these questions, the research seeks to identify potential therapeutic targets and strategies for mitigating the effects of aging on the skeletal system. Additionally, the research will investigate the role of senescence-related pathways and pathogenic mediators in the development and progression of bone and joint diseases.

To gather further insights into the role of aging and cellular senescence in bone and joint diseases, we welcome articles addressing, but not limited to, the following themes:
- The novel mechanism of cellular senescence in bone and joint diseases.
- The role of senescence-related pathways or pathogenic mediators in bone and joint diseases.
- The relationship between organ or system aging (e.g., skin, skeletal muscle, vascular, immune system) and bone and joint diseases.
- The application of new strategies for eliminating senescent cells or reversing the aging phenotype in the treatment of bone and joint diseases.
- Identification of specific aging markers in bone and joint diseases and their role in disease grading, staging, and prognosis.