About this Research Topic
The field of inflammatory response in cardiac surgery is a critical area of research due to the high morbidity and mortality associated with systemic inflammatory response (CS-SIR) evoked by on-pump cardiac surgery. Despite the recognition of this issue, there remains a significant gap in effective treatments to attenuate CS-SIR and improve patient outcomes, primarily because the underlying mechanisms are not fully understood. Previous studies have extensively explored the role of neutrophil activation in CS-SIR, yet this alone does not account for the observed increase in pro-inflammatory factors and localized tissue inflammation. Emerging evidence suggests that T cells, B cells, and monocytes may also play crucial roles in CS-SIR, necessitating a deeper investigation into their contributions. Addressing these gaps is essential for advancing our understanding and developing targeted interventions to mitigate the adverse effects of CS-SIR.
This research topic aims to explore the activation and spatio-temporal variation of T cells, B cells, monocytes, and neutrophils during CS-SIR, as well as the identification of biomarkers and potential treatments derived from these mechanisms. By focusing on the full spectrum of immune changes within the blood system, this research seeks to uncover ideal biomarkers and effective therapies that could significantly enhance the outcomes of on-pump cardiac surgery. The ultimate objective is to clarify the roles of various immune cells in CS-SIR, which may lead to the development of innovative strategies to reduce organ injuries and infections associated with this condition.
To gather further insights into the complex interactions and mechanisms underlying CS-SIR, we welcome articles addressing, but not limited to, the following themes:
- The activation of T cells, B cells, monocytes, and their subsets during CS-SIR and their roles in organ injuries and infection.
- The pattern of NK cells and neutrophils during CS-SIR and their role in organ injuries and infection.
- Specific biomarkers to predict organ injuries and infective events, including cytological markers, molecules expressed on cellular surfaces, genes, pro-inflammatory factors, and substances released by activated cells.
- Techniques for detecting specific biomarkers.
- Factors associated with immune cell activation and biomarkers.
- Preventive or therapeutic measures to attenuate CS-SIR, and thus organ injuries and infective events.
This research topic aims to explore the activation and spatio-temporal variation of T cells, B cells, monocytes, and neutrophils during CS-SIR, as well as the identification of biomarkers and potential treatments derived from these mechanisms. By focusing on the full spectrum of immune changes within the blood system, this research seeks to uncover ideal biomarkers and effective therapies that could significantly enhance the outcomes of on-pump cardiac surgery. The ultimate objective is to clarify the roles of various immune cells in CS-SIR, which may lead to the development of innovative strategies to reduce organ injuries and infections associated with this condition.
To gather further insights into the complex interactions and mechanisms underlying CS-SIR, we welcome articles addressing, but not limited to, the following themes:
- The activation of T cells, B cells, monocytes, and their subsets during CS-SIR and their roles in organ injuries and infection.
- The pattern of NK cells and neutrophils during CS-SIR and their role in organ injuries and infection.
- Specific biomarkers to predict organ injuries and infective events, including cytological markers, molecules expressed on cellular surfaces, genes, pro-inflammatory factors, and substances released by activated cells.
- Techniques for detecting specific biomarkers.
- Factors associated with immune cell activation and biomarkers.
- Preventive or therapeutic measures to attenuate CS-SIR, and thus organ injuries and infective events.
Keywords: cardiac surgery, systemic inflammatory response, mechanism, biomarker, therapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
