Biomedical sensing and detection of disease markers are crucial in clinical diagnosis. In addition to monitoring traditional electrophysiological signals, the detection of biochemical markers within the human body offers valuable information about an individual's health or the presence of specific diseases. Thus, the development of biosensors serves as the foundation for clinical diagnosis, health monitoring, and the advancement of medical instruments. By constructing biosensors, the accuracy and effectiveness of disease diagnosis and health monitoring can be significantly enhanced. Moreover, this advancement will also foster the growth of the medical device industry, which is vital for the sustainable development of human healthcare. Functional devices, such as electrodes modified with nanomaterials or biomaterials, as well as chips designed with specialized structures, represent a popular category within the field of biosensing. These devices aim to address scientific and technical challenges encountered during biomedical research.

With the rapid advancement of biosensing, a wide range of electrochemical and optical biosensors have been developed for the detection and monitoring of disease-related biomarkers. Although significant progress has been made, there are still critical issues that need to be addressed. The stability and repeatability of the biological detection process have not been effectively resolved, leading to reduced credibility of the detection results. Additionally, in certain scenarios, trace detection or long-term monitoring of biomarkers is necessary, but traditional biosensors struggle to achieve this. Fortunately, the development of nanotechnology and microfabrication has paved the way for functional devices with excellent performance and high repeatability. Examples include organic field-effect transistors (OFETs), micro-electrode arrays (MEAs), screen-printed electrodes (SPEs), microfluidic chips, and organic electrochemical transistors (OECTs). These advancements offer possibilities for the further development of biosensors that exhibit high sensitivity, low detection limits, and rapid response. As a result, they hold tremendous promise in the fields of clinical diagnostics and precision medicine.

In light of the rapid advancements in the field of biomedical sensing and detection, our proposed project aims to explore the principles, designs, fabrication methods, and practical applications of functional device-based biosensors. These include organic field-effect transistors (OFETs), micro-electrode arrays (MEAs), screen-printed electrodes (SPEs), microfluidic chips, and organic electrochemical transistors (OECTs), among others. Our primary goal is to establish a comprehensive platform for the exchange of ideas among scientific researchers and engineers.

We cordially invite submissions of Original Research, Review, Mini Review, and Perspective articles on various themes, including but not limited to:
1. Design and fabrication techniques of functional device-based biochemical sensors.
2. Development of portable, wearable, or implantable biosensors utilizing functional devices.
3. Intelligent biosensing applications based on functional devices.
4. Utilization of functional device-based biosensors for disease monitoring and treatment.
5. Integration of biomaterials or nanomaterials with devices for electrochemical or optical biosensing.
6. Functional device-enabled coupling of electrochemical and optical detection methods.
We encourage researchers to contribute their valuable insights and findings to foster advancements in this promising field.

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Frontiers in Bioengineering and Biotechnology

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