About this Research Topic
The field of tissue injury, a common consequence of traumas, infections, or organ transplantations, is a significant contributor to increased mortality rates and socioeconomic burdens. The mechanisms involved in tissue injury include the release of oxidants or pro-inflammatory cytokines, with innate or adaptive immunity playing a notable role in the pathogenetic tissue injury sequence. Despite the advancements in understanding these mechanisms, there is a need for better risk prediction models, therapeutic interventions, and early biomarkers to monitor tissue damage. Recent studies have identified promising candidates for therapeutic targets, including microRNAs and bioactive enzymes, in various clinical conditions. However, the early molecular events and innate immune signaling networks that initiate tissue injury remain poorly defined.
This research topic aims to provide a comprehensive understanding of the pathogenesis and development of tissue injury, particularly focusing on the dynamic molecular process of tissue injury underlying organ transplantation. The goal is to gather pre-clinical and clinical data to provide a joint commentary on prediction molecules that can guide perioperative management and enhance organ protection in transplant recipients. The research will also aim to identify new biomarkers and therapeutic targets for specific tissue injuries.
To gather further insights into the molecular mechanisms and biomarkers of tissue injury, we welcome articles addressing, but not limited to, the following themes: recent advances in regulating innate and adaptive immunity in tissue injury after organ transplantation; modes of pathogen recognition and inflammatory signaling in organ ischemia/reperfusion injury (IRI) and organ transplantation; roles of endogenous molecules in the pathogenesis of organ IRI-transplant inflammatory injury; new insights into the molecular mechanism of immune regulation in tissue injury and repair; identification of new biomarkers in transplant-induced inflammatory responses; and pre-clinical and clinical application of specific biomarkers in solid organ transplantations.
This research topic aims to provide a comprehensive understanding of the pathogenesis and development of tissue injury, particularly focusing on the dynamic molecular process of tissue injury underlying organ transplantation. The goal is to gather pre-clinical and clinical data to provide a joint commentary on prediction molecules that can guide perioperative management and enhance organ protection in transplant recipients. The research will also aim to identify new biomarkers and therapeutic targets for specific tissue injuries.
To gather further insights into the molecular mechanisms and biomarkers of tissue injury, we welcome articles addressing, but not limited to, the following themes: recent advances in regulating innate and adaptive immunity in tissue injury after organ transplantation; modes of pathogen recognition and inflammatory signaling in organ ischemia/reperfusion injury (IRI) and organ transplantation; roles of endogenous molecules in the pathogenesis of organ IRI-transplant inflammatory injury; new insights into the molecular mechanism of immune regulation in tissue injury and repair; identification of new biomarkers in transplant-induced inflammatory responses; and pre-clinical and clinical application of specific biomarkers in solid organ transplantations.
Keywords: Tissue injury, Biomarkers, Molecular signaling, Repair, Inflammation, Innate immunity, Islet Transplantation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
