Infections have been a core challenged traditional healers have been confronted with. It is a very broad field including viral, bacterial, fungal, protozoal and metazoal infections. Therefore, anti-infective plant extracts have played and important role in many societies. At the same time, traditional medicine has also played a unique role in regulating human immunity and improving disease resistance. However, the numbers of plant metabolites developed into antibiotics has been very limited.
Such treatment can help patients to enhance their immunity and improve their resistance by regulating the internal environment of the body, for it to better cope with the invasion of infectious agents. Overall, traditional medical systems on all continents provide many choices and ideas for the treatment and prevention of infectious diseases. Within this research topic, we expect that more effective extracts or metabolites based of traditional medicine will be investigated which help in the treatment of infectious diseases.

This RT will focus on the role, advantages and limitations of metabolites from traditional medicine and chemically well-defined multi-component formulations in treating infectious diseases, using experimental (microbiological and pharmacological) approaches
Specific themes include:
• The efficacy and mechanism of traditional medicine prescriptions in treating infectious diseases;
• Identification of active metabolites responsible for potential medicinal effect: Clarifying the active components of traditional medicine and their mechanism of action is helpful to improve the efficacy and safety of traditional medicine.
• Assessing potential targets for active metabolites using experimental approaches
• Clinical research ideally based on a multi-center and large-sample clinical research of a chemically well-defined traditional medicine to assess its potential efficacy and safety in the treatment of infectious diseases, and provide scientific basis for clinical practice.
• Drug research and development aiming at treating lesser known, neglected or new infectious diseases, incorporating strategies for intellectual property protection to meet the clinical treatment needs.

In general we want to encourage international research cooperations and exchange: which and jointly promote the development and application of traditional medicine globally in the prevention and treatment of infectious diseases. We hope that this research topic will attract researchers from countries where infectious diseases remain core public health challenges

All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).). We also expect that the MS follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205. Please check your MS using https://ga-online.org/best-practice and submit the relevant files (Table 1 and one of the options for Table 2) with your submission.

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