In recent decades, electrochemistry has been exploited to quickly detect toxic chemicals, pollutants, drugs, biologically important compounds, etc., because they bring essential advantages, such as increased sensitivity, small costs, quick response period, and the possibility of on-site monitoring, through miniaturization. As highly sensitive and selective analytical tools, electrochemical sensors are an outstanding choice.

Many reviews have been published so far focussing on the different configurations of electrochemical biosensors depending on the involved bioreagents (enzymes, antibodies or antigens, nucleic acids, peptides) and on the targeted analytes in the clinical, food or environmental fields. However, little attention has been paid to discuss the advances that have taken place from an electrochemical point of view, which play a key role in the improvement of the capabilities that electrochemical biosensors have demonstrated in the last years. When talking about new tools of Electrochemistry at the service of (bio) sensing it should be noted that most of the applications currently performed rely on well-known techniques and materials and involve fundamentals established decades ago. However, as in other areas, there has been a constant evolution in this field leading to the improvement of detection methods. This evolution has been largely assisted by the use of nanomaterials in order to adapt methodologies to the demands that have arisen in current clinical, environmental, food and forensic analysis. Bearing this in mind, this Research Topic critically discusses the recent progresses and achievements made in electrochemical (bio)sensing focusing on the types of electrodes and electrochemical techniques utilized, revisiting also strategies for signal amplification, electrocatalysis, ratiometric designs or antifouling substrates through the discussion of illustrative examples reported in recent literature.

We welcome Original Research, Review, Mini Review and Perspective articles on the following, but not limited to, themes:

• Application of electrochemical impedance spectroscopy for the bioanalysis

• Application of stripping voltammetry for the bioanalysis

• Application of bipolar electrochemistry for the bioanalysis

• Application of single-entity blocking electrochemistry for the bioanalysis

• Application of photo-electrochemistry for the bioanalysis

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Frontiers in Chemistry

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