About this Research Topic
The greatest cause of death for tumor patients is the development of the tumor to other parts of the body, however, what causes tumors to metastasize is still a mystery. Metastasis is a terrible thing once it starts. Fewer than half of the tumor cells that exit the main tumor actually make it to the secondary organ for colonization. Typical cancer cell processes involve a cascade of events, such as tumor cell shedding and intravasation, circulation survival and extravasation, settlement, and proliferation in the secondary organ. A better understanding of the processes at work might lead to the development of more effective methods and treatment targets for preventing cancer spread. Our comprehension of tumor metastasis is enhanced by the "seed-and-soil" idea.
Metastatic tumor cells, like seeds, find their way to particular organ sites, like soil, where they can thrive in a specific environment. Researchers are finding more and more evidence that primary tumors can help with colonization by stimulating the development of a supportive niche in secondary organ sites. More and more people are starting to pay attention to early metastasis and its importance in recent years. The early metastasis is formed through the release of exosomes, cytokines, growth factors, and other signaling molecules. These substances alter the composition of the extracellular matrix of the target organs by attracting immune and stromal cells. This intentionally created microenvironment facilitates the establishment of a suitable environment in remote organs for the infiltration and proliferation of cancer cells, hence promoting their survival, development, and colonization.
The approach has expanded the realm of possibilities for comprehending some of the most captivating inquiries in the field of cancer biology. Research has shown that early metastasis sets up intricate processes at the metastatic site to prepare distant organs for tumor cell colonization. The findings from these investigations shed light on the process of early tumor metastasis, which can help in the development of better diagnostic and treatment tools. To better understand the process of early metastasis, this research topic will try to collect research and review articles summarizing the molecular and cellular features of early metastasis development.
· Role of biological cargos (exosome, cfDNA, cytokines, etc.) in driving the development of metastatic niche
· Remodeling of the physiological parameters at the metastatic site
· Metabolic reprogramming and organotropism in metastatic niche formation
· Early detection markers for metastasis formation
Metastatic tumor cells, like seeds, find their way to particular organ sites, like soil, where they can thrive in a specific environment. Researchers are finding more and more evidence that primary tumors can help with colonization by stimulating the development of a supportive niche in secondary organ sites. More and more people are starting to pay attention to early metastasis and its importance in recent years. The early metastasis is formed through the release of exosomes, cytokines, growth factors, and other signaling molecules. These substances alter the composition of the extracellular matrix of the target organs by attracting immune and stromal cells. This intentionally created microenvironment facilitates the establishment of a suitable environment in remote organs for the infiltration and proliferation of cancer cells, hence promoting their survival, development, and colonization.
The approach has expanded the realm of possibilities for comprehending some of the most captivating inquiries in the field of cancer biology. Research has shown that early metastasis sets up intricate processes at the metastatic site to prepare distant organs for tumor cell colonization. The findings from these investigations shed light on the process of early tumor metastasis, which can help in the development of better diagnostic and treatment tools. To better understand the process of early metastasis, this research topic will try to collect research and review articles summarizing the molecular and cellular features of early metastasis development.
· Role of biological cargos (exosome, cfDNA, cytokines, etc.) in driving the development of metastatic niche
· Remodeling of the physiological parameters at the metastatic site
· Metabolic reprogramming and organotropism in metastatic niche formation
· Early detection markers for metastasis formation
Keywords: premetastatic niche, metastasis, exosomes, cfDNA, tumor microenvironment, ECM-remodeling
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