Stroke is a major cause of long-term disability worldwide, affecting not only physical function but also cognition and mental health. People who have had a stroke often face challenges such as
limited mobility and movement, cognitive difficulties, and vision problems, among other effects that reduce their quality of life. Although there is ample evidence that rehabilitation strategies
combined with adjuvant treatment improve functional outcomes, the factors that affect individual response to these strategies are complex and varied. Personalized stroke rehabilitation approaches promote the most efficient and cost-effective strategies in the clinic. To personalize stroke rehabilitation, we need to understand the intricate relationship between adjuvant treatments, stroke rehabilitation, and the underlying neurobiological mechanisms that support
functional response. Understanding these mechanisms is crucial for developing comprehensive personalized rehabilitation strategies that can successfully integrate adjuvant therapy with stroke rehabilitation to improve function.

The purpose of this Research Topic is to investigate the relationship between stroke rehabilitation, adjuvant therapies, and the neurobiological mechanisms that contribute to
comprehensive personalized recovery in individuals who have experienced a stroke. Our goal is to explore how adjuvant therapies - such as non-invasive brain stimulation, deep brain stimulation, Hebbian learning, aerobic exercise, mindfulness training, and other such therapies - affect functional stroke outcomes, and to identify the neurobiological mechanisms that facilitate these outcomes. These mechanisms can include field potentials, functional connectivity, task-
related activity, neurotransmitter concentrations, blood flow and other vascular measures, brain metabolism indices, tissue integrity, blood and other bodily fluid samples, and motor-evoked
potentials, amongst others. By addressing this problem, we hope to identify the most effective and personalized combination of adjuvant therapy with stroke rehabilitation that can improve clinical, functional, and behavioral outcomes, ultimately leading to a better quality of life for stroke survivors.

We invite authors to submit original research articles, reviews, meta-analyses, clinical trials, and perspectives that offer valuable insights into the connection between stroke rehabilitation, adjuvant therapies, and neurobiological mechanisms. We highly encourage manuscripts that enhance our understanding of current adjuvant therapies by shedding light on the underlying mechanisms and exploring their interaction with stroke rehabilitation outcomes. Contributors are
invited to address various themes related to stroke rehabilitation, adjuvant therapies, and neurobiological mechanisms, including, but not limited to:

• The effects of adjuvant therapies combined with stroke rehabilitation on outcome measures, and how they may be explained by the underlying neurobiology.

• Novel strategies to personalize the combination of adjuvant therapies with stroke rehabilitation that are grounded in the participant’s neurobiology.

• The dosing and timing of adjuvant therapies with stroke rehabilitation in the context of the participant’s neurobiology.

• Developing prediction and triaging models based on the participant’s neurobiology to determine which combination and rehabilitation may provide the greatest positive impact.

• The effects of adjuvants combined with stroke rehabilitation on the neurobiology.

• A description of the potential mechanism of adjuvant therapies combined with stroke rehabilitation in the context of neurobiology.

Submit your idea

Impact

Frontiers in Human Neuroscience

Submit your idea

Impact