Peroxisomes and Nervous Tissues: Unraveling Their Physiologic and Pathologic Role

Peroxisomes, since their discovery by Rhodin and De Duve, have been recognized as essential organelles involved in a myriad of biochemical processes vital for maintaining cellular homeostasis. Traditionally, they have been associated with lipid metabolism and redox balance, but recent research has expanded their known roles to include interactions with other cellular compartments, influencing signaling pathways, immune responses, and aging processes. This newfound understanding has sparked interest in exploring their functions within nervous tissues, where they may play critical roles in maintaining neurological health. Despite these advancements, significant gaps remain in our understanding of how peroxisomes contribute to nervous tissue function and pathology. Current studies have begun to uncover their involvement in neurodegenerative diseases, yet the precise mechanisms and potential therapeutic targets remain elusive, necessitating further investigation.

This research topic aims to explore the complex relationship between peroxisomes and nervous tissues, with the goal of elucidating their physiological and pathological roles. By addressing key questions such as how peroxisomes influence myelin homeostasis, synaptic transmission, and neuronal development, this collection seeks to advance our understanding of their contributions to neurological health. Additionally, the research will investigate the implications of peroxisome dysfunction in neurodegenerative disorders, aiming to identify potential therapeutic interventions targeting peroxisomal pathways.

To gather further insights in the intersection of peroxisomes and nervous tissues, we welcome articles addressing, but not limited to, the following themes:
- Distribution and function of peroxisomes in brain cells and nervous tissues, including the eye.
- Molecular mechanisms governing peroxisomal dynamics in neurons and glial cells.
- Implications of peroxisome dysfunction in neurodegenerative disorders.
- Specialized functions of peroxisomes across different species, from invertebrates to mammals.
- Contributions of peroxisomes to myelin homeostasis, synaptic transmission, and neuronal development.
- Pathogenesis of peroxisomal diseases and their involvement in common neurodegenerative diseases such as Alzheimer’s, leukodystrophies, and retinal degeneration.
- Emergence of biomarkers related to peroxisomal function and dysfunction.
- Innovative methodologies and technologies advancing peroxisome research in nervous tissues.

Keywords: Peroxisomes, nervous tissues, brain, pathology, aging, pathogenesis, myelin homeostasis, glial cells, microglia, neurons, lipid metabolism, redox homeostasis, signaling

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.