About this Research Topic
From the time of their discovery by Rhodin and De Duve, peroxisomes have remained enigmatic organelles, conducting a symphony of biochemical processes crucial for cellular homeostasis. Traditionally acknowledged for their involvement in lipid metabolism and redox homeostasis, peroxisomes have emerged as multifaceted players in cellular processes. Recent advancements have revealed their ability to interact with other cellular compartments, exposing their importance in diverse signaling pathways, inflammatory and immune responses, and aging. This opens an exciting frontier for exploration, especially within nervous tissues.
This Frontiers article collection delves into the intersection of peroxisomes and nervous tissues, seeking to unravel the intricacies of their relationship and shed light on the pivotal roles they play in nervous tissue function and overall health. By consolidating the latest discoveries and technological breakthroughs, this collection sets the stage for future investigations that may ultimately lead to therapeutic interventions targeting peroxisomal pathways in neurological disorders.
The anticipated contributions to this collection, including original research articles, reviews, hypothesis papers, short communications, and clinical reports, will cover a diverse range of topics. These include the distribution and function of peroxisomes in brain cells and nervous tissues, including areas such as the eye. The collection will explore the molecular mechanisms governing peroxisomal dynamics in neurons and glial cells, as well as the implications of peroxisome dysfunction in neurodegenerative disorders. The knowledge presented will span from invertebrates to mammals, providing insights into the specialized functions of peroxisomes. Contributors will address questions about how these organelles contribute to myelin homeostasis, synaptic transmission, neuronal development, and the overall maintenance of neurological health. The collection will shed light on the pathogenesis of peroxisomal disease, and additionally explore peroxisome involvement in more common neurodegenerative diseases, including but not limited to Alzheimer’s, leukodystrophies, and retinal degeneration, as well as the emergence of biomarkers.
Furthermore, the collection may highlight innovative methodologies and technologies driving advancements in peroxisome research within the context of nervous tissues. From advanced imaging techniques to cutting-edge omics approaches, contributors will showcase tools propelling the field forward and enabling a deeper understanding of the cellular and physiological processes in which peroxisomes participate.
This Frontiers article collection delves into the intersection of peroxisomes and nervous tissues, seeking to unravel the intricacies of their relationship and shed light on the pivotal roles they play in nervous tissue function and overall health. By consolidating the latest discoveries and technological breakthroughs, this collection sets the stage for future investigations that may ultimately lead to therapeutic interventions targeting peroxisomal pathways in neurological disorders.
The anticipated contributions to this collection, including original research articles, reviews, hypothesis papers, short communications, and clinical reports, will cover a diverse range of topics. These include the distribution and function of peroxisomes in brain cells and nervous tissues, including areas such as the eye. The collection will explore the molecular mechanisms governing peroxisomal dynamics in neurons and glial cells, as well as the implications of peroxisome dysfunction in neurodegenerative disorders. The knowledge presented will span from invertebrates to mammals, providing insights into the specialized functions of peroxisomes. Contributors will address questions about how these organelles contribute to myelin homeostasis, synaptic transmission, neuronal development, and the overall maintenance of neurological health. The collection will shed light on the pathogenesis of peroxisomal disease, and additionally explore peroxisome involvement in more common neurodegenerative diseases, including but not limited to Alzheimer’s, leukodystrophies, and retinal degeneration, as well as the emergence of biomarkers.
Furthermore, the collection may highlight innovative methodologies and technologies driving advancements in peroxisome research within the context of nervous tissues. From advanced imaging techniques to cutting-edge omics approaches, contributors will showcase tools propelling the field forward and enabling a deeper understanding of the cellular and physiological processes in which peroxisomes participate.
Keywords: Peroxisomes, nervous tissues, brain, pathology, aging, pathogenesis, myelin homeostasis, glial cells, microglia, neurons, lipid metabolism, redox homeostasis, signaling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
