About this Research Topic
Recent advances in musculoskeletal regeneration, particularly in cartilage and bone development and repair, have made substantial progress by combining cell-based techniques with orthobiologics to address cartilage and bone issues. Furthermore, advances in cell culture techniques and bioengineering strategies have enabled the creation of novel platforms for the development and manipulation of stem cells, thereby increasing their curative potential in tissue regeneration. The synergistic combination of cells, biological scaffolds like platelet-rich plasma (PRP), and growth factors, integrated with biomaterials such as scaffolds, enhances restorative benefits by generating an optimal milieu for regenerative growth, extracellular matrix production, structural support, and facilitating tissue integration. Collectively, these interdisciplinary initiatives reflect a paradigm change in musculoskeletal regeneration, opening up new paths for the treatment of cartilage pathologies such as osteoarthritis and chondral defects, intervertebral disc disorders, as well as bone pathologies, while also showing significant potential for improved clinical outcomes.
Pathologies affecting different musculoskeletal tissues, such as articular cartilage, the intervertebral disc, and bone, fail to fully heal on their own due to the limited or inadequate ability of these tissues for spontaneous repair. While various clinical options exist to address these issues, none can replicate the original tissue structures and functions in patients, highlighting the crucial need for innovative alternate therapeutics that can enhance current therapies by stimulating reparative processes. The goal of this Research Topic is to present an overview of the most advanced protocols and procedures that may function as tools to improve the healing of musculoskeletal disorders in future translational approaches.
We expect high-quality original research articles, systematic reviews, and review articles, that delve into various aspects of musculoskeletal regeneration.
Articles may cover the following topics (not limited to the same):
• Cell-free and cell-based approaches in cartilage repair and regeneration
• Chondral pathologies and emerging stem cell therapies
• Orthobiologics in chondral pathologies
• Advancements in scaffolds for musculoskeletal repair
• Role of subchondral bone in cartilage health and repair
Pathologies affecting different musculoskeletal tissues, such as articular cartilage, the intervertebral disc, and bone, fail to fully heal on their own due to the limited or inadequate ability of these tissues for spontaneous repair. While various clinical options exist to address these issues, none can replicate the original tissue structures and functions in patients, highlighting the crucial need for innovative alternate therapeutics that can enhance current therapies by stimulating reparative processes. The goal of this Research Topic is to present an overview of the most advanced protocols and procedures that may function as tools to improve the healing of musculoskeletal disorders in future translational approaches.
We expect high-quality original research articles, systematic reviews, and review articles, that delve into various aspects of musculoskeletal regeneration.
Articles may cover the following topics (not limited to the same):
• Cell-free and cell-based approaches in cartilage repair and regeneration
• Chondral pathologies and emerging stem cell therapies
• Orthobiologics in chondral pathologies
• Advancements in scaffolds for musculoskeletal repair
• Role of subchondral bone in cartilage health and repair
Keywords: Musculoskeletal regeneration, Cartilage repair, Chondrocytes, Stem cells, Orthobiologics, Chondral defects, Intervertebral disc regeneration, Cell-free therapy, Therapeutics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
