Posttranslational modifications (PTMs) allow cells to respond rapidly to changing environmental conditions and signalling cues. These reversible and dynamic modifications play a crucial role in the regulation of protein structure, function, stability, and location, orchestrating complex regulatory networks.
Recent findings have revealed their role in shaping the modulation of critical proteins involved in cell death pathways. For example, the phosphorylation of proteins involved in the apoptotic pathway, such as caspases and Bcl-2 family members, can either activate or inhibit their function, thus regulating the progression of apoptosis. Likewise, ubiquitination, a PTM involving the attachment of ubiquitin molecules to target proteins, known for its role in protein degradation and regulation of various cellular processes has been linked in the control cell death pathways.
In this Research Topic we aim to understand how PTMs, such as phosphorylation, ubiquitination, acetylation, among others, influence the dynamics of the delicate balance between cell survival and death. A clear understanding of the mechanisms that determinate the fate of the cell will pave the way for the identification of potential targets for therapeutic interventions.
This collection therefore welcomes articles of all types (Original Research, Review, Methods, Perspectives, etc.) covering, but not limited to:
- Modulation of cell death pathways by PTMs
- Cross-talk between PTMs and its influence in the balance between cellular life or death
- The role of PTMs in aberrant cell death decisions in the context of diseases, such as cancer or neurodegenerative disorders
- PTMs as sensors of cellular stress and consequent activation of cell death pathways.
Keywords:
Posttranslational Modifications, PTMs, Cell Death Pathways, Cellular Stress
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Posttranslational modifications (PTMs) allow cells to respond rapidly to changing environmental conditions and signalling cues. These reversible and dynamic modifications play a crucial role in the regulation of protein structure, function, stability, and location, orchestrating complex regulatory networks.
Recent findings have revealed their role in shaping the modulation of critical proteins involved in cell death pathways. For example, the phosphorylation of proteins involved in the apoptotic pathway, such as caspases and Bcl-2 family members, can either activate or inhibit their function, thus regulating the progression of apoptosis. Likewise, ubiquitination, a PTM involving the attachment of ubiquitin molecules to target proteins, known for its role in protein degradation and regulation of various cellular processes has been linked in the control cell death pathways.
In this Research Topic we aim to understand how PTMs, such as phosphorylation, ubiquitination, acetylation, among others, influence the dynamics of the delicate balance between cell survival and death. A clear understanding of the mechanisms that determinate the fate of the cell will pave the way for the identification of potential targets for therapeutic interventions.
This collection therefore welcomes articles of all types (Original Research, Review, Methods, Perspectives, etc.) covering, but not limited to:
- Modulation of cell death pathways by PTMs
- Cross-talk between PTMs and its influence in the balance between cellular life or death
- The role of PTMs in aberrant cell death decisions in the context of diseases, such as cancer or neurodegenerative disorders
- PTMs as sensors of cellular stress and consequent activation of cell death pathways.
Keywords:
Posttranslational Modifications, PTMs, Cell Death Pathways, Cellular Stress
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.