Cardiovascular diseases are the leading causes of mortality worldwide, giving rise to substantial global health and economic burdens. Emerging evidence suggests that gut microbiota is closely related to host health and diseases including cardiovascular diseases. Microbes dwelling in the gastrointestinal tract not only act as a key interface for energy acquisition through metabolizing dietary nutrients but also serve as crucial regulators of human physiological functions, especially metabolic homeostasis. Metabolites act as important communication mediators between the host and gut microorganisms with both protective and detrimental effects.

As for cardiovascular diseases, the most extensively studied gut microbial metabolite is trimethylamine N-oxide (TMAO), a gut metabolite generated from choline, betaine, and carnitine. Besides, the roles of short-chain fatty acids, bile acids, and tryptophan metabolites as links between host and gut microbiota have also been gradually recognized in cardiovascular diseases. These gut microbiota-derived metabolites have emerged as diagnostic biomarkers and prognostic predictors of cardiovascular diseases, offering promising therapeutic targets.

A deeper investigation into the roles and regulatory mechanisms of gut microbiota-derived metabolites is still needed. In addition, evidence regarding the clinical application of gut microbiota-derived metabolites in the diagnosis and therapy of cardiovascular disease needs to be accumulated. Comprehensive reviews of existing findings and then pointing out research gaps on gut microbiota-derived metabolites in cardiovascular diseases are also of great significance. This Research Topic aims to collect Original Research and Reviews addressing the questions related to the pivotal role of gut microbiota-derived metabolites in cardiovascular diseases.

The focus areas include, but are not limited to:
• Novel findings of correlations and causal relationships between gut microbiota-derived metabolites and cardiovascular diseases
• Pathogenesis and molecular mechanisms by which gut microbiota-derived metabolites involved in the occurrence or development of cardiovascular diseases
• The impacts of host cardiovascular diseases on the regulation of gut microbial metabolites
• Clinical application of gut microbiota-derived metabolites as diagnostic biomarkers or prognostic predictors of cardiovascular diseases
• Novel cardiovascular disease therapies through the manipulation of gut microbiota-derived metabolites

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Frontiers in Cellular and Infection Microbiology

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