Tubular tissue engineering is at the forefront of regenerative medicine, aiming to replicate the structure and function of natural tubular organs. These organs, including both non-hollow (nerves, tendons, muscles) and hollow (vessels, trachea, esophagus, ureter, urethra, intestine) structures, play critical roles in human physiology. The complexity of their anatomical and physiological characteristics presents unique challenges in creating bioartificial counterparts. Established methods like 3D bioprinting, solution electrospinning, and melt electrowriting have laid the groundwork for replicating these intricate structures. Recent advancements in light-based processing techniques further enhance our ability to create more precise and functional tissue constructs. Understanding and integrating the anatomical hierarchy and physiological functions of these tubular organs is essential for developing effective regenerative therapies and advancing clinical applications.

The primary goal of this research initiative is to address the challenges in synthesizing anatomically accurate and physiologically functional bioartificial tubular organs. By differentiating between non-hollow tubular structures (nerves, tendon, and muscle) and hollow tubular structures (vessels, trachea, esophagus, ureter, urethra, and intestine), this research collection will elucidate how the distinct anatomical and physiological characteristics of each type of tubular organ inform the selection and optimization of advanced fabrication techniques. Recent advancements have shown promise in improving the precision and functionality of engineered tissues. By leveraging established methods like 3D bioprinting, solution electrospinning, and melt electrowriting, along with emerging light-based processing techniques, we aim to enhance the biomimicry and regenerative potential of these constructs. The integration of anatomical and physiological insights with advanced fabrication methods will enable the creation of tubular organs that closely mimic their natural counterparts. This research will also evaluate the translational implications of these techniques, with a focus on developing functional tubular constructs for clinical applications in regenerative medicine and organ replacement therapies.

This research topic invites contributions that explore various aspects of tubular tissue engineering. We seek studies that differentiate between non-hollow and hollow tubular structures, focusing on their unique anatomical and physiological traits. Key themes include:
- Advanced fabrication techniques: 3D bioprinting, solution electrospinning, melt electrowriting, and light-based processing.
- Integration of anatomical hierarchies and physiological functions in tissue engineering.
- Biomimicry in the development of bioartificial tubular organs.
- Translational and clinical implications of engineered tubular constructs.

Authors are encouraged to submit original research, reviews, and case studies that provide insights into the development and application of bioartificial tubular organs, aiming to push the boundaries of regenerative medicine and organ replacement therapies.

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Frontiers in Bioengineering and Biotechnology

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