About this Research Topic
Antimicrobial resistance (AMR) is increasingly recognized as a critical global health threat, particularly due to the emergence of pathogens that can withstand multiple drug treatments. Among the most concerning are the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species), noted for their capacity to "escape" the effects of conventional antibiotics. These bacteria are especially proficient at biofilm formation, a process that significantly enhances their resistance to treatments and their ability to cause persistent infections. Biofilms lead to reinforced virulence and complicate the eradication of infections, especially in hospital settings where they can form on medical devices.
This research topic aims to advance the development of biofilm inhibitors as a critical strategy to boost the effectiveness of existing antibacterial treatments, reduce the incidence of device-associated infections, and tackle the broader issue of multidrug-resistant infections. The goal is to catalyze the establishment and validation of novel therapeutic agents that can disrupt biofilm integrity and enhance pathogen susceptibility to drugs.
To deepen our understanding and refine therapeutic approaches, we aim at gathering further insights focusing on the following sub-themes:
o Natural products
o Synthetic and semi-synthetic drug candidates
o Essential oils
o Antibiofilm peptides
o Quorum quenching enzymes
o Nanoparticles
o Prebiotics, Probiotics, and Synbiotics
o Phage therapy
This research topic welcomes these article types: original research, review, mini-review and opinion.
This research topic aims to advance the development of biofilm inhibitors as a critical strategy to boost the effectiveness of existing antibacterial treatments, reduce the incidence of device-associated infections, and tackle the broader issue of multidrug-resistant infections. The goal is to catalyze the establishment and validation of novel therapeutic agents that can disrupt biofilm integrity and enhance pathogen susceptibility to drugs.
To deepen our understanding and refine therapeutic approaches, we aim at gathering further insights focusing on the following sub-themes:
o Natural products
o Synthetic and semi-synthetic drug candidates
o Essential oils
o Antibiofilm peptides
o Quorum quenching enzymes
o Nanoparticles
o Prebiotics, Probiotics, and Synbiotics
o Phage therapy
This research topic welcomes these article types: original research, review, mini-review and opinion.
Keywords: Antimicrobial resistance, Biofilm Inhibitors, ESKAPE Pathogens, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species
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