About this Research Topic
Pharmacogenomics has emerged as a pivotal field in cancer chemotherapy, addressing both the severe adverse effects and the precision required in therapeutic dosing. Advances in this field underscore the significance of single nucleotide polymorphisms (SNPs), which have been shown to influence both the efficacy and toxicity of treatment. Recent research has increasingly focused on how genetic variations in drug metabolism and cellular transport affect these outcomes. Consequently, improved understanding of these genetic factors is critical for enhancing therapeutic effectiveness and minimizing adverse effects in oncology.
This Research Topic aims to consolidate the latest insights into genetic mutations, particularly SNPs, that impact both the toxicity and efficacy of cancer chemotherapy. It also seeks to evaluate how these mutations alter drug plasma concentration, affecting bioavailability and subsequently, patient outcomes. Additionally, the topic aims to explore the validation of bioanalytical methods for chemotherapy, enhancing therapeutic drug monitoring and ensuring precise drug delivery tailored to individual genetic profiles.
The focus of this collection is on the following key areas:
- Examination of how genetic mutations influence chemotherapy outcomes and toxicity.
- Assessment and validation of bioanalytical methods suitable for effective therapeutic drug monitoring.
- Exploration of genetic impacts on chemotherapy metabolism and transport mechanisms.
- Innovations in dosage prediction models based on pharmacogenetic data.
Drug Metabolism and Transport welcomes submissions of the following article types: Clinical Trial, Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology and Code.
This Research Topic aims to consolidate the latest insights into genetic mutations, particularly SNPs, that impact both the toxicity and efficacy of cancer chemotherapy. It also seeks to evaluate how these mutations alter drug plasma concentration, affecting bioavailability and subsequently, patient outcomes. Additionally, the topic aims to explore the validation of bioanalytical methods for chemotherapy, enhancing therapeutic drug monitoring and ensuring precise drug delivery tailored to individual genetic profiles.
The focus of this collection is on the following key areas:
- Examination of how genetic mutations influence chemotherapy outcomes and toxicity.
- Assessment and validation of bioanalytical methods suitable for effective therapeutic drug monitoring.
- Exploration of genetic impacts on chemotherapy metabolism and transport mechanisms.
- Innovations in dosage prediction models based on pharmacogenetic data.
Drug Metabolism and Transport welcomes submissions of the following article types: Clinical Trial, Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology and Code.
Keywords: Pharmacokinetics, Pharmacogenomics, Bioanalytical Methods, Celluar Transport, Chemotherapy
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