Pharmacogenomics play a crucial role in cancer chemotherapy due to both the high risk of serious side effects and the narrow therapeutic windows of chemotherapy.
Recently, SNPs greatly affect treatment outcomes in cancer for both efficacy and toxicity. More attention has been given for mutation in genes for metabolic or cellular transport enzymes emphasizing the role of pharmacokinetic changes in predicting chemotherapy outcomes and precise medicine application in oncology.
This Research Topic is aimed to highlight recent updates in genetic mutations that affect both the toxicity and efficacy of cancer chemotherapy specially SNPs in genes for drug metabolism and cellular transport with expected changes in drug plasma concentration and bioavailability added to validation methods for chemotherapy bioanalysis for therapeutic drug monitoring.
Manuscripts should focus on one of the following aspects:
1. Exploring the role of genetic mutation on chemotherapy outcomes and toxicity
2. Validation of bioanalytical methods of chemotherapy for therapeutic drug monitoring (TDM)
3. Exploring the role of genetic mutation on chemotherapy metabolism and cellular transport
4. Chemotherapy dose prediction due to pharmacogenetic changes
Drug Metabolism and Transport welcomes submissions of the following article types: Clinical Trial, Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology and Code.
Keywords:
Pharmacokinetics, Pharmacogenomics, Bioanalytical Methods, Celluar Transport, Chemotherapy
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Pharmacogenomics play a crucial role in cancer chemotherapy due to both the high risk of serious side effects and the narrow therapeutic windows of chemotherapy.
Recently, SNPs greatly affect treatment outcomes in cancer for both efficacy and toxicity. More attention has been given for mutation in genes for metabolic or cellular transport enzymes emphasizing the role of pharmacokinetic changes in predicting chemotherapy outcomes and precise medicine application in oncology.
This Research Topic is aimed to highlight recent updates in genetic mutations that affect both the toxicity and efficacy of cancer chemotherapy specially SNPs in genes for drug metabolism and cellular transport with expected changes in drug plasma concentration and bioavailability added to validation methods for chemotherapy bioanalysis for therapeutic drug monitoring.
Manuscripts should focus on one of the following aspects:
1. Exploring the role of genetic mutation on chemotherapy outcomes and toxicity
2. Validation of bioanalytical methods of chemotherapy for therapeutic drug monitoring (TDM)
3. Exploring the role of genetic mutation on chemotherapy metabolism and cellular transport
4. Chemotherapy dose prediction due to pharmacogenetic changes
Drug Metabolism and Transport welcomes submissions of the following article types: Clinical Trial, Correction, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Technology and Code.
Keywords:
Pharmacokinetics, Pharmacogenomics, Bioanalytical Methods, Celluar Transport, Chemotherapy
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.