The stromal microenvironment, made of structural and connective tissues, is increasingly recognized as a central orchestrator of immune responses, thus marking a paradigm shift in our understanding of disease pathogenesis.

Recent scientific investigations illuminate a profound and dynamic interplay between stromal elements and immune effectors, influencing the trajectory of various pathological conditions. This research topic seeks to explore the intricacies of these interactions, placing particular emphasis on state-of-the-art approaches as single-cell omics in unraveling the molecular landscape.

Beyond providing structural support networks, the stroma is now acknowledged as an active participant in immune regulation, orchestrating immune cell trafficking, activation, and differentiation.

Compelling scientific evidence, pointed out the pivotal role of tumor stroma in immune evasion and disease progression. Stromal cells, including fibroblasts, pericytes, mesenchymal and endothelial cells, contribute to the establishment of an immunosuppressive microenvironment, influencing immune cell infiltration and function. Similarly, in chronic inflammatory diseases, aberrant stromal-immune crosstalk perpetuates inflammation and tissue damage.

Unraveling the molecular stromal-immune crosstalk is paramount for advancing novel therapeutic targets and strategies. In this regard, the tremendous potential of single-cell multi-omics technologies, enabling the dissection of heterogeneous cell populations within the stromal microenvironment, will provide a comprehensive view of molecular signatures.

Targeting specific molecular pathways governing these interactions is a burgeoning frontier for modulating immune responses and ameliorating pathological conditions. This research paradigm has the potential to redefine precision therapies, disrupting disease-promoting stromal-immune crosstalk. By inviting researchers to contribute insights to this groundbreaking collection, we aim to advance our understanding of;
- Stromal-immune dynamics,
- Leveraging the power of single-cell technologies and
- Omics analyses to propel translational discoveries.

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Frontiers in Immunology

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